Niemann-Pick C1 Affects the Gene Delivery Efficacy of Degradable Polymeric Nanoparticles

Despite intensive research effort, the rational design of improved nanoparticulate drug carriers remains challenging, in part due to a limited understanding of the determinants of nanoparticle entry and transport in target cells. Recent studies have shown that Niemann-Pick C1 (NPC1), the lysosome me...

Full description

Bibliographic Details
Main Authors: Eltoukhy, Ahmed A. (Contributor), Sahay, Gaurav (Contributor), Cunningham, James M. (Author), Anderson, Daniel Griffith (Contributor)
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: American Chemical Society (ACS), 2016-02-09T16:19:38Z.
Subjects:
Online Access:Get fulltext