In Vivo Silencing of the Transcription Factor IRF5 Reprograms the Macrophage Phenotype and Improves Infarct Healing

In Vivo Silencing of the Transcription Factor IRF5 Reprograms the Macrophage Phenotype and Improves Infarct Healing

Objectives The aim of this study was to test whether silencing of the transcription factor interferon regulatory factor 5 (IRF5) in cardiac macrophages improves infarct healing and attenuates post-myocardial infarction (MI) remodeling. Background In healing wounds, the M1 toward M2 macrophage phenot...

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Main Authors: Courties, Gabriel (Author), Heidt, Timo (Author), Sebas, Matthew (Author), Iwamoto, Yoshiko (Author), Jeon, Derrick (Author), Truelove, Jessica (Author), Tricot, Benoit (Author), Wojtkiewicz, Greg (Author), Dutta, Partha (Author), Sager, Hendrik B. (Author), Borodovsky, Anna (Author), Novobrantseva, Tatiana I. (Author), Klebanov, Boris (Author), Fitzgerald, Kevin (Author), Libby, Peter (Author), Swirski, Filip K. (Author), Weissleder, Ralph (Author), Nahrendorf, Matthias (Author), Anderson, Daniel Griffith (Contributor)
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier, 2016-02-09T15:16:07Z.
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