Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases

Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases

Current antibiotics tend to be broad spectrum, leading to indiscriminate killing of commensal bacteria and accelerated evolution of drug resistance. Here, we use CRISPR-Cas technology to create antimicrobials whose spectrum of activity is chosen by design. RNA-guided nucleases (RGNs) targeting speci...

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Bibliographic Details
Main Authors: Citorik, Robert James (Contributor), Mimee, Mark Kyle (Author), Lu, Timothy K (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor), Massachusetts Institute of Technology. Synthetic Biology Center (Contributor), Mimee, Mark K. (Contributor), Lu, Timothy K. (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2016-01-14T17:03:44Z.
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