Role of ABCB1 C3435T variant in response to antiepileptic drugs in epilepsy: a review

Role of ABCB1 C3435T variant in response to antiepileptic drugs in epilepsy: a review

Over-expression of P-glycoprotein (P-gp), the encoded product of the ATP-binding cassette (ABC), sub-family B, member 1 (ABCB1/MDR1) gene, plays an important role in mediating multidrug resistance to antiepileptic drugs (AEDs) in about 30% of patients with epilepsy. Genetic variation may in part exp...

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Bibliographic Details
Main Authors: Haerian BS (Author), Mohamed Z (Author), Mohamed EHM (Author), Lim KS (Author), Tan HJ (Author), Tan CT (Author), Raymond AA (Author)
Format: Article
Language:English
Published: Penerbit UKM, 2009.
Online Access:Get fulltext

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