Valproic acid for the treatment of refractory pediatric primary bone anaplastic large-cell lymphoma: A case report and literature review

• Main Authors: Randa I Al-Bloushy, Salma H Sait, Ali H Algiraigri
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2020-01-01
• Series: Journal of Applied Hematology
• Subjects: bony anaplastic large-cell lymphoma; lymphoma; valproic acid
• Online Access: http://www.jahjournal.org/article.asp?issn=1658-5127;year=2020;volume=11;issue=2;spage=77;epage=79;aulast=Al-Bloushy

Primary bony anaplastic large-cell lymphoma is quite rare in children but potentially life-threatening lymphoma. Such disease is challenging and often carries a poor prognosis. Here, we report a patient who presented with an aggressive bony lymphoma and failed to respond to conventional chemotherapy; however, he had a robust response to valproic acid, which changed his status from hopeless palliative case to a success story and allowed him to complete his intended chemotherapy protocol.