Multiple serine transposase dimers assemble the transposon-end synaptic complex during IS607-family transposition

Multiple serine transposase dimers assemble the transposon-end synaptic complex during IS607-family transposition

IS607-family transposons are unusual because they do not have terminal inverted repeats or generate target site duplications. They encode two protein-coding genes, but only tnpA is required for transposition. Our X-ray structures confirm that TnpA is a member of the serine recombinase (SR) family, b...

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Bibliographic Details
Main Authors: Wenyang Chen, Sridhar Mandali, Stephen P Hancock, Pramod Kumar, Michael Collazo, Duilio Cascio, Reid C Johnson
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-10-01
Series:eLife
Subjects:
DNA transposition
serine recombinase
nucleoprotein complex
Helicobacter pylori
Mycobacteria tuberculosis
Sulfolobus islandicus
Online Access:https://elifesciences.org/articles/39611

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