A Self-Healing Hierarchical Fiber Hydrogel That Mimics ECM Structure

A Self-Healing Hierarchical Fiber Hydrogel That Mimics ECM Structure

Although there have been many studies on using hydrogels as substitutes for natural extracellular matrices (ECMs), hydrogels that mimic the structure and properties of ECM remain a contentious topic in current research. Herein, a hierarchical biomimetic fiber hydrogel was prepared using a simple str...

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Main Authors: Kai Li, Yuting Zhu, Qiang Zhang, Xiaoli Shi, Feng Liang, Dong Han
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Materials
Subjects:
hydrogel
hierarchy
fiber
self‑healing
wound dressing
Online Access:https://www.mdpi.com/1996-1944/13/22/5277
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spelling doaj-ffe93062fc0243e0a1cbc7fd4f33ebcf2020-11-25T04:01:33ZengMDPI AGMaterials1996-19442020-11-01135277527710.3390/ma13225277A Self-Healing Hierarchical Fiber Hydrogel That Mimics ECM StructureKai Li0Yuting Zhu1Qiang Zhang2Xiaoli Shi3Feng Liang4Dong Han5The State Key Laboratory for Refractories and Metallurgy, Institute of Advanced Materials and Nanotechnology, School of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan 430081, ChinaCenter for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, ChinaCenter for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, ChinaCenter for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, ChinaThe State Key Laboratory for Refractories and Metallurgy, Institute of Advanced Materials and Nanotechnology, School of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan 430081, ChinaCenter for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, ChinaAlthough there have been many studies on using hydrogels as substitutes for natural extracellular matrices (ECMs), hydrogels that mimic the structure and properties of ECM remain a contentious topic in current research. Herein, a hierarchical biomimetic fiber hydrogel was prepared using a simple strategy, with a structure highly similar to that of the ECM. Cell viability experiments showed that the hydrogel not only has good biocompatibility but also promotes cell proliferation and growth. It was also observed that cells adhere to the fibers in the hydrogel, mimicking the state of cells in the ECM. Lastly, through a rat skin wound repair experiment, we demonstrated that this hydrogel has a good effect on promoting rat skin healing. Its high structural similarity to the ECM and good biocompatibility make this hydrogel a good candidate for prospective applications in the field of tissue engineering.https://www.mdpi.com/1996-1944/13/22/5277hydrogelhierarchyfiberself‑healingwound dressing
collection DOAJ
language English
format Article
sources DOAJ
author Kai Li
Yuting Zhu
Qiang Zhang
Xiaoli Shi
Feng Liang
Dong Han
spellingShingle Kai Li
Yuting Zhu
Qiang Zhang
Xiaoli Shi
Feng Liang
Dong Han
A Self-Healing Hierarchical Fiber Hydrogel That Mimics ECM Structure
Materials
hydrogel
hierarchy
fiber
self‑healing
wound dressing
author_facet Kai Li
Yuting Zhu
Qiang Zhang
Xiaoli Shi
Feng Liang
Dong Han
author_sort Kai Li
title A Self-Healing Hierarchical Fiber Hydrogel That Mimics ECM Structure
title_short A Self-Healing Hierarchical Fiber Hydrogel That Mimics ECM Structure
title_full A Self-Healing Hierarchical Fiber Hydrogel That Mimics ECM Structure
title_fullStr A Self-Healing Hierarchical Fiber Hydrogel That Mimics ECM Structure
title_full_unstemmed A Self-Healing Hierarchical Fiber Hydrogel That Mimics ECM Structure
title_sort self-healing hierarchical fiber hydrogel that mimics ecm structure
publisher MDPI AG
series Materials
issn 1996-1944
publishDate 2020-11-01
description Although there have been many studies on using hydrogels as substitutes for natural extracellular matrices (ECMs), hydrogels that mimic the structure and properties of ECM remain a contentious topic in current research. Herein, a hierarchical biomimetic fiber hydrogel was prepared using a simple strategy, with a structure highly similar to that of the ECM. Cell viability experiments showed that the hydrogel not only has good biocompatibility but also promotes cell proliferation and growth. It was also observed that cells adhere to the fibers in the hydrogel, mimicking the state of cells in the ECM. Lastly, through a rat skin wound repair experiment, we demonstrated that this hydrogel has a good effect on promoting rat skin healing. Its high structural similarity to the ECM and good biocompatibility make this hydrogel a good candidate for prospective applications in the field of tissue engineering.
topic hydrogel
hierarchy
fiber
self‑healing
wound dressing
url https://www.mdpi.com/1996-1944/13/22/5277
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