Genetically modified T cells to target glioblastoma

• Main Authors: Simone eKrebs, Tania G Rodríguez-Cruz, Christopher eDeRenzo, Stephen eGottschalk
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2013-12-01
• Series: Frontiers in Oncology
• Subjects: Glioblastoma; T cells; GBM; gene transfer; genetically modified T cells; antigen-specific T cells
• Online Access: http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00322/full

Despite advances in surgical procedures, radiation- and chemotherapy the outcome for patients with glioblastoma (GBM) remains poor. While GBM cells express antigens that are potentially recognized by T cells, GBMs prevent the induction of GBM-specific immune responses by creating an immunosuppressive microenvironment. The advent of gene transfer has allowed the rapid generation of antigen-specific T cells as well as T cells with enhanced effector function. Here we review recent advances in the field of cell therapy with genetically modified T cells and how these advances might improve outcomes for patients with GBM in the future.