Genetically modified T cells to target glioblastoma

Genetically modified T cells to target glioblastoma

Despite advances in surgical procedures, radiation- and chemotherapy the outcome for patients with glioblastoma (GBM) remains poor. While GBM cells express antigens that are potentially recognized by T cells, GBMs prevent the induction of GBM-specific immune responses by creating an immunosuppressiv...

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Bibliographic Details
Main Authors: Simone eKrebs, Tania G Rodríguez-Cruz, Christopher eDeRenzo, Stephen eGottschalk
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-12-01
Series:Frontiers in Oncology
Subjects:
Glioblastoma
T cells
GBM
gene transfer
genetically modified T cells
antigen-specific T cells
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00322/full
Description
Summary:Despite advances in surgical procedures, radiation- and chemotherapy the outcome for patients with glioblastoma (GBM) remains poor. While GBM cells express antigens that are potentially recognized by T cells, GBMs prevent the induction of GBM-specific immune responses by creating an immunosuppressive microenvironment. The advent of gene transfer has allowed the rapid generation of antigen-specific T cells as well as T cells with enhanced effector function. Here we review recent advances in the field of cell therapy with genetically modified T cells and how these advances might improve outcomes for patients with GBM in the future.
ISSN:2234-943X

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