A novel angiotensin I-converting enzyme mutation (S333W) impairs N-domain enzymatic cleavage of the anti-fibrotic peptide, AcSDKP.

A novel angiotensin I-converting enzyme mutation (S333W) impairs N-domain enzymatic cleavage of the anti-fibrotic peptide, AcSDKP.

BACKGROUND: Angiotensin I-converting enzyme (ACE) has two functional N- and C-domain active centers that display differences in the metabolism of biologically-active peptides including the hemoregulatory tetrapeptide, Ac-SDKP, hydrolysed preferentially by the N domain active center. Elevated Ac-SDKP...

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Bibliographic Details
Main Authors: Sergei M Danilov, Michael S Wade, Sylva L Schwager, Ross G Douglas, Andrew B Nesterovitch, Isolda A Popova, Kyle D Hogarth, Nakul Bhardwaj, David E Schwartz, Edward D Sturrock, Joe G N Garcia
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3913711?pdf=render

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