Antidiabetic Agent DPP-4i Facilitates Murine Breast Cancer Metastasis by Oncogenic ROS-NRF2-HO-1 Axis via a Positive NRF2-HO-1 Feedback Loop

Antidiabetic Agent DPP-4i Facilitates Murine Breast Cancer Metastasis by Oncogenic ROS-NRF2-HO-1 Axis via a Positive NRF2-HO-1 Feedback Loop

Cancer has been as one of common comorbidities of diabetes. Long-term antidiabetic treatment may potentially exert uncertain impacts on diabetic patients with cancer including breast cancer (BC). Dipeptidyl peptidase-4 inhibitors (DPP-4i) are currently recommended by the AACE as first-line hypoglyce...

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Bibliographic Details
Main Authors: Rui Li, Xin Zeng, Meihua Yang, Xiaohui Xu, Jinmei Feng, Liming Bao, Bingqian Xue, Xin Wang, Yi Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Oncology
Subjects:
DPP-4 inhibitor
NRF2
HO-1 (heme oxygenase-1)
metastasis
breast cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.679816/full

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