Development of AAV Variants with Human Hepatocyte Tropism and Neutralizing Antibody Escape Capacity

Development of AAV Variants with Human Hepatocyte Tropism and Neutralizing Antibody Escape Capacity

Adeno-associated virus (AAV) vectors have been successfully used in patients with bleeding disorders and blindness. For human liver targeting, two major factors restrict effective AAV transduction after systemic administration of AAV vectors: human hepatocyte tropism and neutralizing antibodies (Nab...

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Bibliographic Details
Main Authors: Xiaolei Pei, Wenwei Shao, Allene Xing, Charles Askew, Xiaojing Chen, Caibin Cui, Yasmina L. Abajas, David A. Gerber, Elizabeth P. Merricks, Timothy C. Nichols, Wuping Li, R. Jude Samulski, Chengwen Li
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
AAV
human hepatocyte
tropism
Nabs
chimeric mice
Online Access:http://www.sciencedirect.com/science/article/pii/S232905012030125X

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