Propofol Induces Apoptosis of Neurons but Not Astrocytes, Oligodendrocytes, or Neural Stem Cells in the Neonatal Mouse Hippocampus

Propofol Induces Apoptosis of Neurons but Not Astrocytes, Oligodendrocytes, or Neural Stem Cells in the Neonatal Mouse Hippocampus

It has been shown that propofol can induce widespread apoptosis in neonatal mouse brains followed by long-term cognitive dysfunction. However, selective brain area and cell vulnerability to propofol remains unknown. This study was aimed to dissect toxic effect of propofol on multiple brain cells, in...

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Bibliographic Details
Main Authors: Yasheng Yan, Shigang Qiao, Chika Kikuchi, Ivan Zaja, Sarah Logan, Congshan Jiang, Thiago Arzua, Xiaowen Bai
Format: Article
Language:English
Published: MDPI AG 2017-10-01
Series:Brain Sciences
Subjects:
propofol
apoptosis
neurons
astrocytes
oligodendrocytes
neural stem cells
selective vulnerability
Online Access:https://www.mdpi.com/2076-3425/7/10/130

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