Plumbagin inhibits invasion and migration of breast and gastric cancer cells by downregulating the expression of chemokine receptor CXCR4

Plumbagin inhibits invasion and migration of breast and gastric cancer cells by downregulating the expression of chemokine receptor CXCR4

<p>Abstract</p> <p>Background</p> <p>Increasing evidence indicates that the interaction between the CXC chemokine receptor-4 (CXCR4) and its ligand CXCL12 is critical in the process of metastasis that accounts for more than 90% of cancer-related deaths. Thus, novel agen...

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Bibliographic Details
Main Authors: Bist Pradeep, Ramesh Bhargavi, Kapoor Shweta, Vali Shireen, Swamy Shivananju, Kannaiyan Radhamani, Hay Hui, Ramachandran Lalitha, Li Feng, Rajendran Peramaiyan, Shanmugam Muthu K, Manu Kanjoormana, Koay Evelyn S, Lim Lina HK, Ahn Kwang, Kumar Alan, Sethi Gautam
Format: Article
Language:English
Published: BMC 2011-09-01
Series:Molecular Cancer
Online Access:http://www.molecular-cancer.com/content/10/1/107

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