EXPERIMENTAL MODULATION OF HEp-2p TUMORAL CELLS REACTIVITY TO THE ACTION OF SOME AUTOCHTHONOUS POLYPHENOLIC CYTOSTATICS BY CERTAIN MEMBRANOTROPIC AND METABOLIC AGENTS (I)

• Main Authors: Pincu Rotinberg, Daniela Gherghel, Mihai Cosmin, Ion Neacsu, Helen Rotinberg
• Format: Article
• Language: English
• Published: "Alexandru Ioan Cuza" University of Iași 2007-08-01
• Series: Analele Ştiinţifice Ale Universităţii Alexandru Ioan Cuza din Iași,Sectiunea II A : Genetica si Biologie Moleculara
• Online Access: http://www.gbm.bio.uaic.ro/index.php/gbm/article/view/388

The in vitro short-lasting treatment of the HEp-2p human tumoral cells, initially sensitized by some standard cytophysiological agents, with the autochthonous POLYAS cytostatic biopreparation has been correlated with quantitative and qualitative modification of the reactivity profile of some membrane phenomena. The sense and amplitude of the modulation of the POLYAS characteristic effects upon membrane enzymatic (Na + –K + –ATP-ase) and bioelectrical (RMP) activities have revealed the functional synergism, antagonism or complementarity between the agents used in an associated type treatment. This different functional relations between POLYAS and K + or Ca 2+ ions, ouabaine or chemically modified nystatine, adrenaline or ascorbic acid, are due to their interactions with similar or different membrane receptors and can influence the cytostatic potential of the POLYAS polyphenolic biopreparation.