OPTIMIZATION OF EXPERIMENTAL INDUSTRIAL TECHNOLOGY OF SILICON-CONTAINING DERIVATIVES OF POLYOL SUBSTANCES PRODUCTION

The process of the synthesis of silicon-containing glycerol derivatives of Si(С3H7O3)4 ∙ 6С3Н8O3 composition was optimized on the example of creation of the experimental industrial technology of the drug substance «Silativit» production. The main criterion of optimization was reducing a time and en...

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Main Authors:	A. A. Boyko, S. V. Mordanov, T. G. Khonina, O. N. Chupahin
Format:	Article
Language:	Russian
Published:	LLC Center of Pharmaceutical Analytics (LLC «CPHA») 2019-01-01
Series:	Разработка и регистрация лекарственных средств
Subjects:	transesterification of silanes silicon derivatives of polyols catalysis computational hydrodynamics
Online Access:	https://www.pharmjournal.ru/jour/article/view/415

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spelling	doaj-ffc7627ff3334d0bb9869712be1eed8e2021-07-28T13:06:55ZrusLLC Center of Pharmaceutical Analytics (LLC «CPHA»)Разработка и регистрация лекарственных средств2305-20662658-50492019-01-0102108114415OPTIMIZATION OF EXPERIMENTAL INDUSTRIAL TECHNOLOGY OF SILICON-CONTAINING DERIVATIVES OF POLYOL SUBSTANCES PRODUCTIONA. A. Boyko0S. V. Mordanov1T. G. Khonina2O. N. Chupahin3I.Ya. Postovsky Institute of Organic Synthesis of Ural Branch of the Russian Academy of SciencesChemical Engineering Institute of the Ural Federal University, Department of «Machinery and equipment of chemical plants»I.Ya. Postovsky Institute of Organic Synthesis of Ural Branch of the Russian Academy of SciencesI.Ya. Postovsky Institute of Organic Synthesis of Ural Branch of the Russian Academy of SciencesThe process of the synthesis of silicon-containing glycerol derivatives of Si(С3H7O3)4 ∙ 6С3Н8O3 composition was optimized on the example of creation of the experimental industrial technology of the drug substance «Silativit» production. The main criterion of optimization was reducing a time and energy expenditure on carrying out the synthesis, representing heterophase reaction of alcoholysis of initial alkoxysilane by polyol. Optimization was performed on such indicators of process as temperature condition, the mode of removal of an easily volatile product of reaction, the mode of mixture of reactionary weight and type of the used mixing device.https://www.pharmjournal.ru/jour/article/view/415transesterification of silanessilicon derivatives of polyolscatalysiscomputational hydrodynamics
collection	DOAJ
language	Russian
format	Article
sources	DOAJ
author	A. A. Boyko S. V. Mordanov T. G. Khonina O. N. Chupahin
spellingShingle	A. A. Boyko S. V. Mordanov T. G. Khonina O. N. Chupahin OPTIMIZATION OF EXPERIMENTAL INDUSTRIAL TECHNOLOGY OF SILICON-CONTAINING DERIVATIVES OF POLYOL SUBSTANCES PRODUCTION Разработка и регистрация лекарственных средств transesterification of silanes silicon derivatives of polyols catalysis computational hydrodynamics
author_facet	A. A. Boyko S. V. Mordanov T. G. Khonina O. N. Chupahin
author_sort	A. A. Boyko
title	OPTIMIZATION OF EXPERIMENTAL INDUSTRIAL TECHNOLOGY OF SILICON-CONTAINING DERIVATIVES OF POLYOL SUBSTANCES PRODUCTION
title_short	OPTIMIZATION OF EXPERIMENTAL INDUSTRIAL TECHNOLOGY OF SILICON-CONTAINING DERIVATIVES OF POLYOL SUBSTANCES PRODUCTION
title_full	OPTIMIZATION OF EXPERIMENTAL INDUSTRIAL TECHNOLOGY OF SILICON-CONTAINING DERIVATIVES OF POLYOL SUBSTANCES PRODUCTION
title_fullStr	OPTIMIZATION OF EXPERIMENTAL INDUSTRIAL TECHNOLOGY OF SILICON-CONTAINING DERIVATIVES OF POLYOL SUBSTANCES PRODUCTION
title_full_unstemmed	OPTIMIZATION OF EXPERIMENTAL INDUSTRIAL TECHNOLOGY OF SILICON-CONTAINING DERIVATIVES OF POLYOL SUBSTANCES PRODUCTION
title_sort	optimization of experimental industrial technology of silicon-containing derivatives of polyol substances production
publisher	LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
series	Разработка и регистрация лекарственных средств
issn	2305-2066 2658-5049
publishDate	2019-01-01
description	The process of the synthesis of silicon-containing glycerol derivatives of Si(С3H7O3)4 ∙ 6С3Н8O3 composition was optimized on the example of creation of the experimental industrial technology of the drug substance «Silativit» production. The main criterion of optimization was reducing a time and energy expenditure on carrying out the synthesis, representing heterophase reaction of alcoholysis of initial alkoxysilane by polyol. Optimization was performed on such indicators of process as temperature condition, the mode of removal of an easily volatile product of reaction, the mode of mixture of reactionary weight and type of the used mixing device.
topic	transesterification of silanes silicon derivatives of polyols catalysis computational hydrodynamics
url	https://www.pharmjournal.ru/jour/article/view/415
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OPTIMIZATION OF EXPERIMENTAL INDUSTRIAL TECHNOLOGY OF SILICON-CONTAINING DERIVATIVES OF POLYOL SUBSTANCES PRODUCTION

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