OPTIMIZATION OF EXPERIMENTAL INDUSTRIAL TECHNOLOGY OF SILICON-CONTAINING DERIVATIVES OF POLYOL SUBSTANCES PRODUCTION

OPTIMIZATION OF EXPERIMENTAL INDUSTRIAL TECHNOLOGY OF SILICON-CONTAINING DERIVATIVES OF POLYOL SUBSTANCES PRODUCTION

The process of the synthesis of silicon-containing glycerol derivatives of Si(С3H7O3)4 ∙ 6С3Н8O3  composition was optimized on the example of creation of the experimental industrial technology of the drug substance «Silativit» production. The main criterion of optimization was reducing a time and en...

Full description

Bibliographic Details
Main Authors: A. A. Boyko, S. V. Mordanov, T. G. Khonina, O. N. Chupahin
Format: Article
Language:Russian
Published: LLC Center of Pharmaceutical Analytics (LLC «CPHA») 2019-01-01
Series:Разработка и регистрация лекарственных средств
Subjects:
transesterification of silanes
silicon derivatives of polyols
catalysis
computational hydrodynamics
Online Access:https://www.pharmjournal.ru/jour/article/view/415
Description
Summary:The process of the synthesis of silicon-containing glycerol derivatives of Si(С3H7O3)4 ∙ 6С3Н8O3  composition was optimized on the example of creation of the experimental industrial technology of the drug substance «Silativit» production. The main criterion of optimization was reducing a time and energy expenditure on carrying out the synthesis, representing heterophase reaction of alcoholysis of initial alkoxysilane by polyol. Optimization was performed on such indicators of process as temperature condition, the mode of removal of an easily volatile product of reaction, the mode of mixture of reactionary weight and type of the used mixing device.
ISSN:2305-2066
2658-5049

Similar Items