GABA through the Ages: Regulation of Cortical Function and Plasticity by Inhibitory Interneurons

GABA through the Ages: Regulation of Cortical Function and Plasticity by Inhibitory Interneurons

Inhibitory interneurons comprise only about 20% of cortical neurons and thus constitute a clear minority compared to the vast number of excitatory projection neurons. They are, however, an influential minority with important roles in cortical maturation, function, and plasticity. In this paper, we w...

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Main Authors: Konrad Lehmann, André Steinecke, Jürgen Bolz
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Neural Plasticity
Online Access:http://dx.doi.org/10.1155/2012/892784
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spelling doaj-ffc6ae7d2ac748b4820a2ba4dfa8d0d12020-11-24T21:23:17ZengHindawi LimitedNeural Plasticity2090-59041687-54432012-01-01201210.1155/2012/892784892784GABA through the Ages: Regulation of Cortical Function and Plasticity by Inhibitory InterneuronsKonrad Lehmann0André Steinecke1Jürgen Bolz2Institut für Allgemeine Zoologie und Tierphysiologie, Universität Jena, 07743 Jena, GermanyInstitut für Allgemeine Zoologie und Tierphysiologie, Universität Jena, 07743 Jena, GermanyInstitut für Allgemeine Zoologie und Tierphysiologie, Universität Jena, 07743 Jena, GermanyInhibitory interneurons comprise only about 20% of cortical neurons and thus constitute a clear minority compared to the vast number of excitatory projection neurons. They are, however, an influential minority with important roles in cortical maturation, function, and plasticity. In this paper, we will highlight the functional importance of cortical inhibition throughout brain development, starting with the embryonal formation of the cortex, proceeding by the regulation of sensory cortical plasticity in adulthood, and finishing with the GABA involvement in sensory information processing in old age.http://dx.doi.org/10.1155/2012/892784
collection DOAJ
language English
format Article
sources DOAJ
author Konrad Lehmann
André Steinecke
Jürgen Bolz
spellingShingle Konrad Lehmann
André Steinecke
Jürgen Bolz
GABA through the Ages: Regulation of Cortical Function and Plasticity by Inhibitory Interneurons
Neural Plasticity
author_facet Konrad Lehmann
André Steinecke
Jürgen Bolz
author_sort Konrad Lehmann
title GABA through the Ages: Regulation of Cortical Function and Plasticity by Inhibitory Interneurons
title_short GABA through the Ages: Regulation of Cortical Function and Plasticity by Inhibitory Interneurons
title_full GABA through the Ages: Regulation of Cortical Function and Plasticity by Inhibitory Interneurons
title_fullStr GABA through the Ages: Regulation of Cortical Function and Plasticity by Inhibitory Interneurons
title_full_unstemmed GABA through the Ages: Regulation of Cortical Function and Plasticity by Inhibitory Interneurons
title_sort gaba through the ages: regulation of cortical function and plasticity by inhibitory interneurons
publisher Hindawi Limited
series Neural Plasticity
issn 2090-5904
1687-5443
publishDate 2012-01-01
description Inhibitory interneurons comprise only about 20% of cortical neurons and thus constitute a clear minority compared to the vast number of excitatory projection neurons. They are, however, an influential minority with important roles in cortical maturation, function, and plasticity. In this paper, we will highlight the functional importance of cortical inhibition throughout brain development, starting with the embryonal formation of the cortex, proceeding by the regulation of sensory cortical plasticity in adulthood, and finishing with the GABA involvement in sensory information processing in old age.
url http://dx.doi.org/10.1155/2012/892784
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AT andresteinecke gabathroughtheagesregulationofcorticalfunctionandplasticitybyinhibitoryinterneurons
AT jurgenbolz gabathroughtheagesregulationofcorticalfunctionandplasticitybyinhibitoryinterneurons
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