The Gut Microbiome and Metabolome of Two Riparian Communities in the Amazon
During the last decades it has become increasingly clear that the microbes that live on and in humans are critical for health. The communities they form, termed microbiomes, are involved in fundamental processes such as the maturation and constant regulation of the immune system. Additionally, they...
Main Authors: | , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2019-09-01
|
Series: | Frontiers in Microbiology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fmicb.2019.02003/full |
id |
doaj-ffc4859f14fb4f8c8369107002e58144 |
---|---|
record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Eder Soares Pires Eder Soares Pires Cristiane Cassiolato Pires Hardoim Karla Rodrigues Miranda Danielle Angst Secco Leandro Araújo Lobo Denise Pires de Carvalho Jun Han Christoph H. Borchers Christoph H. Borchers Christoph H. Borchers Christoph H. Borchers Rosana B. R. Ferreira Joana Falcão Salles Regina Maria Cavalcanti Pilotto Domingues Luis Caetano Martha Antunes Luis Caetano Martha Antunes |
spellingShingle |
Eder Soares Pires Eder Soares Pires Cristiane Cassiolato Pires Hardoim Karla Rodrigues Miranda Danielle Angst Secco Leandro Araújo Lobo Denise Pires de Carvalho Jun Han Christoph H. Borchers Christoph H. Borchers Christoph H. Borchers Christoph H. Borchers Rosana B. R. Ferreira Joana Falcão Salles Regina Maria Cavalcanti Pilotto Domingues Luis Caetano Martha Antunes Luis Caetano Martha Antunes The Gut Microbiome and Metabolome of Two Riparian Communities in the Amazon Frontiers in Microbiology gut microbiome riparian communities Amazon high-throughput sequencing metabolic prediction metabolomics |
author_facet |
Eder Soares Pires Eder Soares Pires Cristiane Cassiolato Pires Hardoim Karla Rodrigues Miranda Danielle Angst Secco Leandro Araújo Lobo Denise Pires de Carvalho Jun Han Christoph H. Borchers Christoph H. Borchers Christoph H. Borchers Christoph H. Borchers Rosana B. R. Ferreira Joana Falcão Salles Regina Maria Cavalcanti Pilotto Domingues Luis Caetano Martha Antunes Luis Caetano Martha Antunes |
author_sort |
Eder Soares Pires |
title |
The Gut Microbiome and Metabolome of Two Riparian Communities in the Amazon |
title_short |
The Gut Microbiome and Metabolome of Two Riparian Communities in the Amazon |
title_full |
The Gut Microbiome and Metabolome of Two Riparian Communities in the Amazon |
title_fullStr |
The Gut Microbiome and Metabolome of Two Riparian Communities in the Amazon |
title_full_unstemmed |
The Gut Microbiome and Metabolome of Two Riparian Communities in the Amazon |
title_sort |
gut microbiome and metabolome of two riparian communities in the amazon |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Microbiology |
issn |
1664-302X |
publishDate |
2019-09-01 |
description |
During the last decades it has become increasingly clear that the microbes that live on and in humans are critical for health. The communities they form, termed microbiomes, are involved in fundamental processes such as the maturation and constant regulation of the immune system. Additionally, they constitute a strong defense barrier to invading pathogens, and are also intricately linked to nutrition. The parameters that affect the establishment and maintenance of these microbial communities are diverse, and include the genetic background, mode of birth, nutrition, hygiene, and host lifestyle in general. Here, we describe the characterization of the gut microbiome of individuals living in the Amazon, and the comparison of these microbial communities to those found in individuals from an urban, industrialized setting. Our results showed striking differences in microbial communities from these two types of populations. Additionally, we used high-throughput metabolomics to study the chemical ecology of the gut environment and found significant metabolic changes between the two populations. Although we cannot point out a single cause for the microbial and metabolic changes observed between Amazonian and urban individuals, they are likely to include dietary differences as well as diverse patterns of environmental exposure. To our knowledge, this is the first description of gut microbial and metabolic profiles in Amazonian populations, and it provides a starting point for thorough characterizations of the impact of individual environmental conditions on the human microbiome and metabolome. |
topic |
gut microbiome riparian communities Amazon high-throughput sequencing metabolic prediction metabolomics |
url |
https://www.frontiersin.org/article/10.3389/fmicb.2019.02003/full |
work_keys_str_mv |
AT edersoarespires thegutmicrobiomeandmetabolomeoftworipariancommunitiesintheamazon AT edersoarespires thegutmicrobiomeandmetabolomeoftworipariancommunitiesintheamazon AT cristianecassiolatopireshardoim thegutmicrobiomeandmetabolomeoftworipariancommunitiesintheamazon AT karlarodriguesmiranda thegutmicrobiomeandmetabolomeoftworipariancommunitiesintheamazon AT danielleangstsecco thegutmicrobiomeandmetabolomeoftworipariancommunitiesintheamazon AT leandroaraujolobo thegutmicrobiomeandmetabolomeoftworipariancommunitiesintheamazon AT denisepiresdecarvalho thegutmicrobiomeandmetabolomeoftworipariancommunitiesintheamazon AT junhan thegutmicrobiomeandmetabolomeoftworipariancommunitiesintheamazon AT christophhborchers thegutmicrobiomeandmetabolomeoftworipariancommunitiesintheamazon AT christophhborchers thegutmicrobiomeandmetabolomeoftworipariancommunitiesintheamazon AT christophhborchers thegutmicrobiomeandmetabolomeoftworipariancommunitiesintheamazon AT christophhborchers thegutmicrobiomeandmetabolomeoftworipariancommunitiesintheamazon AT rosanabrferreira thegutmicrobiomeandmetabolomeoftworipariancommunitiesintheamazon AT joanafalcaosalles thegutmicrobiomeandmetabolomeoftworipariancommunitiesintheamazon AT reginamariacavalcantipilottodomingues thegutmicrobiomeandmetabolomeoftworipariancommunitiesintheamazon AT luiscaetanomarthaantunes thegutmicrobiomeandmetabolomeoftworipariancommunitiesintheamazon AT luiscaetanomarthaantunes thegutmicrobiomeandmetabolomeoftworipariancommunitiesintheamazon AT edersoarespires gutmicrobiomeandmetabolomeoftworipariancommunitiesintheamazon AT edersoarespires gutmicrobiomeandmetabolomeoftworipariancommunitiesintheamazon AT cristianecassiolatopireshardoim gutmicrobiomeandmetabolomeoftworipariancommunitiesintheamazon AT karlarodriguesmiranda gutmicrobiomeandmetabolomeoftworipariancommunitiesintheamazon AT danielleangstsecco gutmicrobiomeandmetabolomeoftworipariancommunitiesintheamazon AT leandroaraujolobo gutmicrobiomeandmetabolomeoftworipariancommunitiesintheamazon AT denisepiresdecarvalho gutmicrobiomeandmetabolomeoftworipariancommunitiesintheamazon AT junhan gutmicrobiomeandmetabolomeoftworipariancommunitiesintheamazon AT christophhborchers gutmicrobiomeandmetabolomeoftworipariancommunitiesintheamazon AT christophhborchers gutmicrobiomeandmetabolomeoftworipariancommunitiesintheamazon AT christophhborchers gutmicrobiomeandmetabolomeoftworipariancommunitiesintheamazon AT christophhborchers gutmicrobiomeandmetabolomeoftworipariancommunitiesintheamazon AT rosanabrferreira gutmicrobiomeandmetabolomeoftworipariancommunitiesintheamazon AT joanafalcaosalles gutmicrobiomeandmetabolomeoftworipariancommunitiesintheamazon AT reginamariacavalcantipilottodomingues gutmicrobiomeandmetabolomeoftworipariancommunitiesintheamazon AT luiscaetanomarthaantunes gutmicrobiomeandmetabolomeoftworipariancommunitiesintheamazon AT luiscaetanomarthaantunes gutmicrobiomeandmetabolomeoftworipariancommunitiesintheamazon |
_version_ |
1725244698848657408 |
spelling |
doaj-ffc4859f14fb4f8c8369107002e581442020-11-25T00:51:38ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2019-09-011010.3389/fmicb.2019.02003462710The Gut Microbiome and Metabolome of Two Riparian Communities in the AmazonEder Soares Pires0Eder Soares Pires1Cristiane Cassiolato Pires Hardoim2Karla Rodrigues Miranda3Danielle Angst Secco4Leandro Araújo Lobo5Denise Pires de Carvalho6Jun Han7Christoph H. Borchers8Christoph H. Borchers9Christoph H. Borchers10Christoph H. Borchers11Rosana B. R. Ferreira12Joana Falcão Salles13Regina Maria Cavalcanti Pilotto Domingues14Luis Caetano Martha Antunes15Luis Caetano Martha Antunes16Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, BrazilInstituto Tecnológico Vale – Desenvolvimento Sustentável, Belém, BrazilInstituto de Biociências, Universidade Estadual Paulista, São Vicente, BrazilInstituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, BrazilInstituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, BrazilInstituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, BrazilInstituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, aRio de Janeiro, BrazilUniversity of Victoria – Genome British Columbia Proteomics Centre, University of Victoria, Victoria, BC, CanadaUniversity of Victoria – Genome British Columbia Proteomics Centre, University of Victoria, Victoria, BC, CanadaDepartment of Biochemistry and Microbiology, University of Victoria, Victoria, BC, CanadaSegal Cancer Proteomics Centre, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, QC, CanadaGerald Bronfman Department of Oncology, Jewish General Hospital, McGill University, Montreal, QC, CanadaInstituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, BrazilMicrobial Ecology Cluster, Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, NetherlandsInstituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil0Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil1Instituto Nacional de Ciência e Tecnologia de Inovação em Doenças de Populações Negligenciadas, Centro de Desenvolvimento Tecnológico em Saúde, Fundação Oswaldo Cruz, Rio de Janeiro, BrazilDuring the last decades it has become increasingly clear that the microbes that live on and in humans are critical for health. The communities they form, termed microbiomes, are involved in fundamental processes such as the maturation and constant regulation of the immune system. Additionally, they constitute a strong defense barrier to invading pathogens, and are also intricately linked to nutrition. The parameters that affect the establishment and maintenance of these microbial communities are diverse, and include the genetic background, mode of birth, nutrition, hygiene, and host lifestyle in general. Here, we describe the characterization of the gut microbiome of individuals living in the Amazon, and the comparison of these microbial communities to those found in individuals from an urban, industrialized setting. Our results showed striking differences in microbial communities from these two types of populations. Additionally, we used high-throughput metabolomics to study the chemical ecology of the gut environment and found significant metabolic changes between the two populations. Although we cannot point out a single cause for the microbial and metabolic changes observed between Amazonian and urban individuals, they are likely to include dietary differences as well as diverse patterns of environmental exposure. To our knowledge, this is the first description of gut microbial and metabolic profiles in Amazonian populations, and it provides a starting point for thorough characterizations of the impact of individual environmental conditions on the human microbiome and metabolome.https://www.frontiersin.org/article/10.3389/fmicb.2019.02003/fullgut microbiomeriparian communitiesAmazonhigh-throughput sequencingmetabolic predictionmetabolomics |