Papillomavirus Immune Evasion Strategies Target the Infected Cell and the Local Immune System

Papillomavirus Immune Evasion Strategies Target the Infected Cell and the Local Immune System

Persistent infection with human papillomavirus (HPV) initiates ~5% of all human cancers, and particularly cervical and oropharyngeal cancers. HPV vaccines prevent HPV infection, but do not eliminate existing HPV infections. Papillomaviruses induce hyperproliferation of epithelial cells. In this revi...

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Bibliographic Details
Main Authors: Chenhao Zhou, Zewen Kelvin Tuong, Ian Hector Frazer
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Oncology
Subjects:
human papillomaviruses (HPVs)
HPV-associated cancers
cervical cancer
HPV16
E7 oncoprotein
immune evasion
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00682/full
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spelling doaj-ffbfc2cdc61943fc9eb65d924880eb172020-11-24T22:05:47ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2019-08-01910.3389/fonc.2019.00682465494Papillomavirus Immune Evasion Strategies Target the Infected Cell and the Local Immune SystemChenhao Zhou0Zewen Kelvin Tuong1Zewen Kelvin Tuong2Ian Hector Frazer3Faculty of Medicine, The University of Queensland Diamantina Institute, Translational Research Institute, The University of Queensland, Brisbane, QLD, AustraliaFaculty of Medicine, The University of Queensland Diamantina Institute, Translational Research Institute, The University of Queensland, Brisbane, QLD, AustraliaMolecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge, United KingdomFaculty of Medicine, The University of Queensland Diamantina Institute, Translational Research Institute, The University of Queensland, Brisbane, QLD, AustraliaPersistent infection with human papillomavirus (HPV) initiates ~5% of all human cancers, and particularly cervical and oropharyngeal cancers. HPV vaccines prevent HPV infection, but do not eliminate existing HPV infections. Papillomaviruses induce hyperproliferation of epithelial cells. In this review we discuss how hyperproliferation renders epithelial cells less sensitive to immune attack, and impacts upon the efficiency of the local immune system. These observations have significance for the design of therapeutic HPV cancer immunotherapies.https://www.frontiersin.org/article/10.3389/fonc.2019.00682/fullhuman papillomaviruses (HPVs)HPV-associated cancerscervical cancerHPV16E7 oncoproteinimmune evasion
collection DOAJ
language English
format Article
sources DOAJ
author Chenhao Zhou
Zewen Kelvin Tuong
Zewen Kelvin Tuong
Ian Hector Frazer
spellingShingle Chenhao Zhou
Zewen Kelvin Tuong
Zewen Kelvin Tuong
Ian Hector Frazer
Papillomavirus Immune Evasion Strategies Target the Infected Cell and the Local Immune System
Frontiers in Oncology
human papillomaviruses (HPVs)
HPV-associated cancers
cervical cancer
HPV16
E7 oncoprotein
immune evasion
author_facet Chenhao Zhou
Zewen Kelvin Tuong
Zewen Kelvin Tuong
Ian Hector Frazer
author_sort Chenhao Zhou
title Papillomavirus Immune Evasion Strategies Target the Infected Cell and the Local Immune System
title_short Papillomavirus Immune Evasion Strategies Target the Infected Cell and the Local Immune System
title_full Papillomavirus Immune Evasion Strategies Target the Infected Cell and the Local Immune System
title_fullStr Papillomavirus Immune Evasion Strategies Target the Infected Cell and the Local Immune System
title_full_unstemmed Papillomavirus Immune Evasion Strategies Target the Infected Cell and the Local Immune System
title_sort papillomavirus immune evasion strategies target the infected cell and the local immune system
publisher Frontiers Media S.A.
series Frontiers in Oncology
issn 2234-943X
publishDate 2019-08-01
description Persistent infection with human papillomavirus (HPV) initiates ~5% of all human cancers, and particularly cervical and oropharyngeal cancers. HPV vaccines prevent HPV infection, but do not eliminate existing HPV infections. Papillomaviruses induce hyperproliferation of epithelial cells. In this review we discuss how hyperproliferation renders epithelial cells less sensitive to immune attack, and impacts upon the efficiency of the local immune system. These observations have significance for the design of therapeutic HPV cancer immunotherapies.
topic human papillomaviruses (HPVs)
HPV-associated cancers
cervical cancer
HPV16
E7 oncoprotein
immune evasion
url https://www.frontiersin.org/article/10.3389/fonc.2019.00682/full
work_keys_str_mv AT chenhaozhou papillomavirusimmuneevasionstrategiestargettheinfectedcellandthelocalimmunesystem
AT zewenkelvintuong papillomavirusimmuneevasionstrategiestargettheinfectedcellandthelocalimmunesystem
AT zewenkelvintuong papillomavirusimmuneevasionstrategiestargettheinfectedcellandthelocalimmunesystem
AT ianhectorfrazer papillomavirusimmuneevasionstrategiestargettheinfectedcellandthelocalimmunesystem
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