Papillomavirus Immune Evasion Strategies Target the Infected Cell and the Local Immune System

Papillomavirus Immune Evasion Strategies Target the Infected Cell and the Local Immune System

Persistent infection with human papillomavirus (HPV) initiates ~5% of all human cancers, and particularly cervical and oropharyngeal cancers. HPV vaccines prevent HPV infection, but do not eliminate existing HPV infections. Papillomaviruses induce hyperproliferation of epithelial cells. In this revi...

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Bibliographic Details
Main Authors: Chenhao Zhou, Zewen Kelvin Tuong, Ian Hector Frazer
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Oncology
Subjects:
human papillomaviruses (HPVs)
HPV-associated cancers
cervical cancer
HPV16
E7 oncoprotein
immune evasion
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00682/full
Description
Summary:Persistent infection with human papillomavirus (HPV) initiates ~5% of all human cancers, and particularly cervical and oropharyngeal cancers. HPV vaccines prevent HPV infection, but do not eliminate existing HPV infections. Papillomaviruses induce hyperproliferation of epithelial cells. In this review we discuss how hyperproliferation renders epithelial cells less sensitive to immune attack, and impacts upon the efficiency of the local immune system. These observations have significance for the design of therapeutic HPV cancer immunotherapies.
ISSN:2234-943X

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