Differential Effect of Growth on Development between AGA and SGA Preterm Infants

Predicting developmental outcomes with growth measurement would be beneficial for primary healthcare or in developing countries with low medical resources. This study aimed to identify physical growth measures that indicate neurodevelopment in very preterm infants. Preterm infants, born at <32 we...

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Main Authors: In Gyu Song, Ee-Kyung Kim, Hannah Cho, Seung Han Shin, Jin A Sohn, Han-Suk Kim
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Environmental Research and Public Health
Subjects:
Online Access:https://www.mdpi.com/1660-4601/17/9/3022
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spelling doaj-ffb69cb4706647bb9132c855e76e85292020-11-25T02:10:32ZengMDPI AGInternational Journal of Environmental Research and Public Health1661-78271660-46012020-04-01173022302210.3390/ijerph17093022Differential Effect of Growth on Development between AGA and SGA Preterm InfantsIn Gyu Song0Ee-Kyung Kim1Hannah Cho2Seung Han Shin3Jin A Sohn4Han-Suk Kim5National Hospice Center, National Cancer Center, Goyang-si 10408, KoreaDepartment of Pediatrics, Seoul National University Children’s Hospital, Seoul National University College of Medicine, Seoul 03080, KoreaDepartment of Pediatrics, Korea University Anam Hospital, Seoul 02857, KoreaDepartment of Pediatrics, Seoul National University Children’s Hospital, Seoul National University College of Medicine, Seoul 03080, KoreaDepartment of Pediatrics, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul 07061, KoreaDepartment of Pediatrics, Seoul National University Children’s Hospital, Seoul National University College of Medicine, Seoul 03080, KoreaPredicting developmental outcomes with growth measurement would be beneficial for primary healthcare or in developing countries with low medical resources. This study aimed to identify physical growth measures that indicate neurodevelopment in very preterm infants. Preterm infants, born at <32 weeks’ gestation or weighing <1500 g, were included. We calculated the changes in z-score of weight, length, and head circumference (HC) at different time points: birth, postmenstrual age (PMA) 35 weeks, and 4 and 18 months corrected age (CA). We examined the relationship between growth and Bayley-III scores using linear regression. Among 122 infants, HC at 4 months CA and HC growth between PMA 35 weeks and 4 months CA showed a positive correlation with Bayley-III scores in appropriate-for-gestational-age infants (AGAs). Weight and length increases between birth and 18 months CA were also associated with AGAs’ development. In small-for-gestational-age infants (SGAs), only birthweight’s z-score was associated with improved neurodevelopmental outcomes. HC at 4 months CA was an important indicator of favorable neurodevelopmental outcomes, and head growth spurt between PMA 35 weeks and 4 months CA contributed to this benefit in preterm AGAs. The period and indices should be monitored differently for SGAs and AGAs.https://www.mdpi.com/1660-4601/17/9/3022head circumferencegrowthneurodevelopmentpreterm infantsmall for gestational age
collection DOAJ
language English
format Article
sources DOAJ
author In Gyu Song
Ee-Kyung Kim
Hannah Cho
Seung Han Shin
Jin A Sohn
Han-Suk Kim
spellingShingle In Gyu Song
Ee-Kyung Kim
Hannah Cho
Seung Han Shin
Jin A Sohn
Han-Suk Kim
Differential Effect of Growth on Development between AGA and SGA Preterm Infants
International Journal of Environmental Research and Public Health
head circumference
growth
neurodevelopment
preterm infant
small for gestational age
author_facet In Gyu Song
Ee-Kyung Kim
Hannah Cho
Seung Han Shin
Jin A Sohn
Han-Suk Kim
author_sort In Gyu Song
title Differential Effect of Growth on Development between AGA and SGA Preterm Infants
title_short Differential Effect of Growth on Development between AGA and SGA Preterm Infants
title_full Differential Effect of Growth on Development between AGA and SGA Preterm Infants
title_fullStr Differential Effect of Growth on Development between AGA and SGA Preterm Infants
title_full_unstemmed Differential Effect of Growth on Development between AGA and SGA Preterm Infants
title_sort differential effect of growth on development between aga and sga preterm infants
publisher MDPI AG
series International Journal of Environmental Research and Public Health
issn 1661-7827
1660-4601
publishDate 2020-04-01
description Predicting developmental outcomes with growth measurement would be beneficial for primary healthcare or in developing countries with low medical resources. This study aimed to identify physical growth measures that indicate neurodevelopment in very preterm infants. Preterm infants, born at <32 weeks’ gestation or weighing <1500 g, were included. We calculated the changes in z-score of weight, length, and head circumference (HC) at different time points: birth, postmenstrual age (PMA) 35 weeks, and 4 and 18 months corrected age (CA). We examined the relationship between growth and Bayley-III scores using linear regression. Among 122 infants, HC at 4 months CA and HC growth between PMA 35 weeks and 4 months CA showed a positive correlation with Bayley-III scores in appropriate-for-gestational-age infants (AGAs). Weight and length increases between birth and 18 months CA were also associated with AGAs’ development. In small-for-gestational-age infants (SGAs), only birthweight’s z-score was associated with improved neurodevelopmental outcomes. HC at 4 months CA was an important indicator of favorable neurodevelopmental outcomes, and head growth spurt between PMA 35 weeks and 4 months CA contributed to this benefit in preterm AGAs. The period and indices should be monitored differently for SGAs and AGAs.
topic head circumference
growth
neurodevelopment
preterm infant
small for gestational age
url https://www.mdpi.com/1660-4601/17/9/3022
work_keys_str_mv AT ingyusong differentialeffectofgrowthondevelopmentbetweenagaandsgapreterminfants
AT eekyungkim differentialeffectofgrowthondevelopmentbetweenagaandsgapreterminfants
AT hannahcho differentialeffectofgrowthondevelopmentbetweenagaandsgapreterminfants
AT seunghanshin differentialeffectofgrowthondevelopmentbetweenagaandsgapreterminfants
AT jinasohn differentialeffectofgrowthondevelopmentbetweenagaandsgapreterminfants
AT hansukkim differentialeffectofgrowthondevelopmentbetweenagaandsgapreterminfants
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