Differential Effect of Growth on Development between AGA and SGA Preterm Infants
Predicting developmental outcomes with growth measurement would be beneficial for primary healthcare or in developing countries with low medical resources. This study aimed to identify physical growth measures that indicate neurodevelopment in very preterm infants. Preterm infants, born at <32 we...
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doaj-ffb69cb4706647bb9132c855e76e85292020-11-25T02:10:32ZengMDPI AGInternational Journal of Environmental Research and Public Health1661-78271660-46012020-04-01173022302210.3390/ijerph17093022Differential Effect of Growth on Development between AGA and SGA Preterm InfantsIn Gyu Song0Ee-Kyung Kim1Hannah Cho2Seung Han Shin3Jin A Sohn4Han-Suk Kim5National Hospice Center, National Cancer Center, Goyang-si 10408, KoreaDepartment of Pediatrics, Seoul National University Children’s Hospital, Seoul National University College of Medicine, Seoul 03080, KoreaDepartment of Pediatrics, Korea University Anam Hospital, Seoul 02857, KoreaDepartment of Pediatrics, Seoul National University Children’s Hospital, Seoul National University College of Medicine, Seoul 03080, KoreaDepartment of Pediatrics, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul 07061, KoreaDepartment of Pediatrics, Seoul National University Children’s Hospital, Seoul National University College of Medicine, Seoul 03080, KoreaPredicting developmental outcomes with growth measurement would be beneficial for primary healthcare or in developing countries with low medical resources. This study aimed to identify physical growth measures that indicate neurodevelopment in very preterm infants. Preterm infants, born at <32 weeks’ gestation or weighing <1500 g, were included. We calculated the changes in z-score of weight, length, and head circumference (HC) at different time points: birth, postmenstrual age (PMA) 35 weeks, and 4 and 18 months corrected age (CA). We examined the relationship between growth and Bayley-III scores using linear regression. Among 122 infants, HC at 4 months CA and HC growth between PMA 35 weeks and 4 months CA showed a positive correlation with Bayley-III scores in appropriate-for-gestational-age infants (AGAs). Weight and length increases between birth and 18 months CA were also associated with AGAs’ development. In small-for-gestational-age infants (SGAs), only birthweight’s z-score was associated with improved neurodevelopmental outcomes. HC at 4 months CA was an important indicator of favorable neurodevelopmental outcomes, and head growth spurt between PMA 35 weeks and 4 months CA contributed to this benefit in preterm AGAs. The period and indices should be monitored differently for SGAs and AGAs.https://www.mdpi.com/1660-4601/17/9/3022head circumferencegrowthneurodevelopmentpreterm infantsmall for gestational age |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
In Gyu Song Ee-Kyung Kim Hannah Cho Seung Han Shin Jin A Sohn Han-Suk Kim |
spellingShingle |
In Gyu Song Ee-Kyung Kim Hannah Cho Seung Han Shin Jin A Sohn Han-Suk Kim Differential Effect of Growth on Development between AGA and SGA Preterm Infants International Journal of Environmental Research and Public Health head circumference growth neurodevelopment preterm infant small for gestational age |
author_facet |
In Gyu Song Ee-Kyung Kim Hannah Cho Seung Han Shin Jin A Sohn Han-Suk Kim |
author_sort |
In Gyu Song |
title |
Differential Effect of Growth on Development between AGA and SGA Preterm Infants |
title_short |
Differential Effect of Growth on Development between AGA and SGA Preterm Infants |
title_full |
Differential Effect of Growth on Development between AGA and SGA Preterm Infants |
title_fullStr |
Differential Effect of Growth on Development between AGA and SGA Preterm Infants |
title_full_unstemmed |
Differential Effect of Growth on Development between AGA and SGA Preterm Infants |
title_sort |
differential effect of growth on development between aga and sga preterm infants |
publisher |
MDPI AG |
series |
International Journal of Environmental Research and Public Health |
issn |
1661-7827 1660-4601 |
publishDate |
2020-04-01 |
description |
Predicting developmental outcomes with growth measurement would be beneficial for primary healthcare or in developing countries with low medical resources. This study aimed to identify physical growth measures that indicate neurodevelopment in very preterm infants. Preterm infants, born at <32 weeks’ gestation or weighing <1500 g, were included. We calculated the changes in z-score of weight, length, and head circumference (HC) at different time points: birth, postmenstrual age (PMA) 35 weeks, and 4 and 18 months corrected age (CA). We examined the relationship between growth and Bayley-III scores using linear regression. Among 122 infants, HC at 4 months CA and HC growth between PMA 35 weeks and 4 months CA showed a positive correlation with Bayley-III scores in appropriate-for-gestational-age infants (AGAs). Weight and length increases between birth and 18 months CA were also associated with AGAs’ development. In small-for-gestational-age infants (SGAs), only birthweight’s z-score was associated with improved neurodevelopmental outcomes. HC at 4 months CA was an important indicator of favorable neurodevelopmental outcomes, and head growth spurt between PMA 35 weeks and 4 months CA contributed to this benefit in preterm AGAs. The period and indices should be monitored differently for SGAs and AGAs. |
topic |
head circumference growth neurodevelopment preterm infant small for gestational age |
url |
https://www.mdpi.com/1660-4601/17/9/3022 |
work_keys_str_mv |
AT ingyusong differentialeffectofgrowthondevelopmentbetweenagaandsgapreterminfants AT eekyungkim differentialeffectofgrowthondevelopmentbetweenagaandsgapreterminfants AT hannahcho differentialeffectofgrowthondevelopmentbetweenagaandsgapreterminfants AT seunghanshin differentialeffectofgrowthondevelopmentbetweenagaandsgapreterminfants AT jinasohn differentialeffectofgrowthondevelopmentbetweenagaandsgapreterminfants AT hansukkim differentialeffectofgrowthondevelopmentbetweenagaandsgapreterminfants |
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