Compartmentalised RNA catalysis in membrane-free coacervate protocells

Compartmentalised RNA catalysis in membrane-free coacervate protocells

Phase separation of mixtures of oppositely charged polymers provides a simple and direct route to compartmentalisation via coacervation. Here authors demonstrate that a coacervate microenvironment supports RNA catalysis whilst selectively sequestering RNA based on length.

Bibliographic Details
Main Authors: Björn Drobot, Juan M. Iglesias-Artola, Kristian Le Vay, Viktoria Mayr, Mrityunjoy Kar, Moritz Kreysing, Hannes Mutschler, T-Y Dora Tang
Format: Article
Language:English
Published: Nature Publishing Group 2018-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06072-w
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spelling doaj-ffa9ae58dd1c47ec95dba2093bd693d42021-05-11T09:43:44ZengNature Publishing GroupNature Communications2041-17232018-09-01911910.1038/s41467-018-06072-wCompartmentalised RNA catalysis in membrane-free coacervate protocellsBjörn Drobot0Juan M. Iglesias-Artola1Kristian Le Vay2Viktoria Mayr3Mrityunjoy Kar4Moritz Kreysing5Hannes Mutschler6T-Y Dora Tang7Max-Planck Institute for Molecular Cell Biology and GeneticsMax-Planck Institute for Molecular Cell Biology and GeneticsMax-Planck Institute for BiochemistryMax-Planck Institute for BiochemistryMax-Planck Institute for Molecular Cell Biology and GeneticsMax-Planck Institute for Molecular Cell Biology and GeneticsMax-Planck Institute for BiochemistryMax-Planck Institute for Molecular Cell Biology and GeneticsPhase separation of mixtures of oppositely charged polymers provides a simple and direct route to compartmentalisation via coacervation. Here authors demonstrate that a coacervate microenvironment supports RNA catalysis whilst selectively sequestering RNA based on length.https://doi.org/10.1038/s41467-018-06072-w
collection DOAJ
language English
format Article
sources DOAJ
author Björn Drobot
Juan M. Iglesias-Artola
Kristian Le Vay
Viktoria Mayr
Mrityunjoy Kar
Moritz Kreysing
Hannes Mutschler
T-Y Dora Tang
spellingShingle Björn Drobot
Juan M. Iglesias-Artola
Kristian Le Vay
Viktoria Mayr
Mrityunjoy Kar
Moritz Kreysing
Hannes Mutschler
T-Y Dora Tang
Compartmentalised RNA catalysis in membrane-free coacervate protocells
Nature Communications
author_facet Björn Drobot
Juan M. Iglesias-Artola
Kristian Le Vay
Viktoria Mayr
Mrityunjoy Kar
Moritz Kreysing
Hannes Mutschler
T-Y Dora Tang
author_sort Björn Drobot
title Compartmentalised RNA catalysis in membrane-free coacervate protocells
title_short Compartmentalised RNA catalysis in membrane-free coacervate protocells
title_full Compartmentalised RNA catalysis in membrane-free coacervate protocells
title_fullStr Compartmentalised RNA catalysis in membrane-free coacervate protocells
title_full_unstemmed Compartmentalised RNA catalysis in membrane-free coacervate protocells
title_sort compartmentalised rna catalysis in membrane-free coacervate protocells
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-09-01
description Phase separation of mixtures of oppositely charged polymers provides a simple and direct route to compartmentalisation via coacervation. Here authors demonstrate that a coacervate microenvironment supports RNA catalysis whilst selectively sequestering RNA based on length.
url https://doi.org/10.1038/s41467-018-06072-w
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AT juanmiglesiasartola compartmentalisedrnacatalysisinmembranefreecoacervateprotocells
AT kristianlevay compartmentalisedrnacatalysisinmembranefreecoacervateprotocells
AT viktoriamayr compartmentalisedrnacatalysisinmembranefreecoacervateprotocells
AT mrityunjoykar compartmentalisedrnacatalysisinmembranefreecoacervateprotocells
AT moritzkreysing compartmentalisedrnacatalysisinmembranefreecoacervateprotocells
AT hannesmutschler compartmentalisedrnacatalysisinmembranefreecoacervateprotocells
AT tydoratang compartmentalisedrnacatalysisinmembranefreecoacervateprotocells
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