A Quest for Initiating Cells of Head and Neck Cancer and Their Treatment

A Quest for Initiating Cells of Head and Neck Cancer and Their Treatment

The biology of head and neck squamous cell carcinomas (HNSCC) and other cancers have been related to cancer stem-like cells (CSC). Specific markers, which vary considerably depending on tumor type or tissue of origin, characterize CSC. CSC are cancer initiating, sustaining and mostly quiescent. Comp...

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Main Authors: Andreas M. Kaufmann, Andreas E. Albers, Beate Köberle, Chao Chen
Format: Article
Language:English
Published: MDPI AG 2010-07-01
Series:Cancers
Subjects:
metastasis
stemness
ALDH1
Sox2
Nanog
Oct3/4
human papillomavirus
immunotherapy
chemoresistance
radioresistance
epithelial mesenchymal transition
Online Access:http://www.mdpi.com/2072-6694/2/3/1528/
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spelling doaj-ff92414292244355acd34fea2daab33f2020-11-24T20:45:30ZengMDPI AGCancers2072-66942010-07-01231528155410.3390/cancers2031528A Quest for Initiating Cells of Head and Neck Cancer and Their TreatmentAndreas M. KaufmannAndreas E. AlbersBeate KöberleChao ChenThe biology of head and neck squamous cell carcinomas (HNSCC) and other cancers have been related to cancer stem-like cells (CSC). Specific markers, which vary considerably depending on tumor type or tissue of origin, characterize CSC. CSC are cancer initiating, sustaining and mostly quiescent. Compared to bulk tumors, CSC are less sensitive to chemo- and radiotherapy and may have low immunogenicity. Therapeutic targeting of CSC may improve clinical outcome. HNSCC has two main etiologies: human papillomavirus, a virus infecting epithelial stem cells, and tobacco and alcohol abuse. Here, current knowledge of HNSCC-CSC biology is reviewed and parallels to CSC of other origin are drawn where necessary for a comprehensive picture. http://www.mdpi.com/2072-6694/2/3/1528/metastasisstemnessALDH1Sox2NanogOct3/4human papillomavirusimmunotherapychemoresistanceradioresistanceepithelial mesenchymal transition
collection DOAJ
language English
format Article
sources DOAJ
author Andreas M. Kaufmann
Andreas E. Albers
Beate Köberle
Chao Chen
spellingShingle Andreas M. Kaufmann
Andreas E. Albers
Beate Köberle
Chao Chen
A Quest for Initiating Cells of Head and Neck Cancer and Their Treatment
Cancers
metastasis
stemness
ALDH1
Sox2
Nanog
Oct3/4
human papillomavirus
immunotherapy
chemoresistance
radioresistance
epithelial mesenchymal transition
author_facet Andreas M. Kaufmann
Andreas E. Albers
Beate Köberle
Chao Chen
author_sort Andreas M. Kaufmann
title A Quest for Initiating Cells of Head and Neck Cancer and Their Treatment
title_short A Quest for Initiating Cells of Head and Neck Cancer and Their Treatment
title_full A Quest for Initiating Cells of Head and Neck Cancer and Their Treatment
title_fullStr A Quest for Initiating Cells of Head and Neck Cancer and Their Treatment
title_full_unstemmed A Quest for Initiating Cells of Head and Neck Cancer and Their Treatment
title_sort quest for initiating cells of head and neck cancer and their treatment
publisher MDPI AG
series Cancers
issn 2072-6694
publishDate 2010-07-01
description The biology of head and neck squamous cell carcinomas (HNSCC) and other cancers have been related to cancer stem-like cells (CSC). Specific markers, which vary considerably depending on tumor type or tissue of origin, characterize CSC. CSC are cancer initiating, sustaining and mostly quiescent. Compared to bulk tumors, CSC are less sensitive to chemo- and radiotherapy and may have low immunogenicity. Therapeutic targeting of CSC may improve clinical outcome. HNSCC has two main etiologies: human papillomavirus, a virus infecting epithelial stem cells, and tobacco and alcohol abuse. Here, current knowledge of HNSCC-CSC biology is reviewed and parallels to CSC of other origin are drawn where necessary for a comprehensive picture.
topic metastasis
stemness
ALDH1
Sox2
Nanog
Oct3/4
human papillomavirus
immunotherapy
chemoresistance
radioresistance
epithelial mesenchymal transition
url http://www.mdpi.com/2072-6694/2/3/1528/
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