A Strategic Target Rescues Trimethoprim Sensitivity in Escherichia coli
Summary: Trimethoprim, a preferred treatment for urinary tract infections, is becoming obsolete owing to the rapid dissemination of resistant E. coli. Although direct resistance mechanisms such as overexpression of a mutant FolA and dfr enzymes are well characterized, associated alterations that dri...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-04-01
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| Series: | iScience |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S258900422030170X |