Crimean-Congo hemorrhagic fever virus strains Hoti and Afghanistan cause viremia and mild clinical disease in cynomolgus monkeys.

Crimean-Congo hemorrhagic fever virus strains Hoti and Afghanistan cause viremia and mild clinical disease in cynomolgus monkeys.

<h4>Background</h4>Development of vaccines and therapies against Crimean-Congo hemorrhagic fever virus (CCHFV) have been hindered by the lack of immunocompetent animal models. Recently, a lethal nonhuman primate model based on the CCHFV Hoti strain was reported. CCHFV Hoti caused severe...

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Bibliographic Details
Main Authors: Robert W Cross, Abhishek N Prasad, Viktoriya Borisevich, Joan B Geisbert, Krystle N Agans, Daniel J Deer, Karla A Fenton, Thomas W Geisbert
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-08-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://doi.org/10.1371/journal.pntd.0008637

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