The frequency of hypoparathyroidism in patients with Beta-thalassemia in Hamadan - Iran

• Main Authors: Zahra Razavi (MD), Hasan Bazmamoun (MD), Mohammad Sadegh Saba (MD)
• Format: Article
• Language: fas
• Published: Golestan University of Medical Sciences 2009-03-01
• Series: مجله دانشگاه علوم پزشکی گرگان
• Subjects: Hypocalcemia; Hypoparathyroidism; Beta-Thalassemia
• Online Access: http://goums.ac.ir/journal/browse.php?a_code=A-10-1-329&slc_lang=en&sid=1
• ISSN: 1562-4765; 2008-4080

Background and Objective: The thalassemic syndromes are geneticaly structural disturbance of Alfa and Beta globin chains. In major Beta-thalassemia the life expectancy depended on frequent blood transfusions that lead to over storage and deposition of Iron in different body-organs (Hemochromatosis) including parathyroid glands, which may cause hupoparathyroidism. This study was done to evaluate the frequency of hypoparathyroidism in thalassemic patients referred to teaching hospitals in Hamedan – Iran. Materials and Methods: This descriptive, cross-sectional study was done on 56 thalassemic patients, which received blood transfusion. Serum Ca , P , PTH , total protein , albumin , Ferritin and BUN cratinine were checked two weeks after last transfusion. The hypoparathyroidism was defined when calcium was less than 8mg/dl and phosphorus more than 5.5mg/dl and PTH less than 10 ng/dl. Results: In this study, 14.2% of patients had hypoparathyroidism. 37.5% of hypoparathyroid ones had clinical manifestation of hypocalcemia. There were statistically meaningful association (P<0.05) between The hypoparathyroidism with desferal administration, splenectomy and diabetes. Conclusion: This study showed that the frequency of hypoparathyroidism in Beta-thalassemic patients receiving blood transfusion was relatively high, so clinical and labratory evaluation for endocrine glands specially parathyroid is recommended since early second decay of life.