Amino Acid Metabolic Vulnerabilities in Acute and Chronic Myeloid Leukemias

Amino Acid Metabolic Vulnerabilities in Acute and Chronic Myeloid Leukemias

Amino acid (AA) metabolism plays an important role in many cellular processes including energy production, immune function, and purine and pyrimidine synthesis. Cancer cells therefore require increased AA uptake and undergo metabolic reprogramming to satisfy the energy demand associated with their r...

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Bibliographic Details
Main Authors: Aboli Bhingarkar, Hima V. Vangapandu, Sanjay Rathod, Keito Hoshitsuki, Christian A. Fernandez
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Oncology
Subjects:
non-essential amino acid
GCN2
general control non-derepressible 2
mTORC1
myeloid leukemias
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.694526/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.694526/full

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