MDA5 and TLR3 initiate pro-inflammatory signaling pathways leading to rhinovirus-induced airways inflammation and hyperresponsiveness.

MDA5 and TLR3 initiate pro-inflammatory signaling pathways leading to rhinovirus-induced airways inflammation and hyperresponsiveness.

Rhinovirus (RV), a single-stranded RNA picornavirus, is the most frequent cause of asthma exacerbations. We previously demonstrated in human bronchial epithelial cells that melanoma differentiation-associated gene (MDA)-5 and the adaptor protein for Toll-like receptor (TLR)-3 are each required for m...

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Main Authors: Qiong Wang, David J Miller, Emily R Bowman, Deepti R Nagarkar, Dina Schneider, Ying Zhao, Marisa J Linn, Adam M Goldsmith, J Kelley Bentley, Umadevi S Sajjan, Marc B Hershenson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-05-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3102730?pdf=render

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