FBXO32 promotes microenvironment underlying epithelial-mesenchymal transition via CtBP1 during tumour metastasis and brain development

FBXO32 promotes microenvironment underlying epithelial-mesenchymal transition via CtBP1 during tumour metastasis and brain development

Epithelial-to-mesenchymal transition (EMT) regulates both processes of organism development and changes in cell state causing disease. Here, the authors show that an E3 ubiquitin ligase, FBXO32, regulates EMT via CtBP1 and the transcriptional program, and also mediates cancer metastatic burden and n...

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Main Authors: Sanjeeb Kumar Sahu, Neha Tiwari, Abhijeet Pataskar, Yuan Zhuang, Marina Borisova, Mustafa Diken, Susanne Strand, Petra Beli, Vijay K. Tiwari
Format: Article
Language:English
Published: Nature Publishing Group 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01366-x
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spelling doaj-ff716e030bc54097b27f5ef7fddc1f222021-05-11T07:25:28ZengNature Publishing GroupNature Communications2041-17232017-11-018111810.1038/s41467-017-01366-xFBXO32 promotes microenvironment underlying epithelial-mesenchymal transition via CtBP1 during tumour metastasis and brain developmentSanjeeb Kumar Sahu0Neha Tiwari1Abhijeet Pataskar2Yuan Zhuang3Marina Borisova4Mustafa Diken5Susanne Strand6Petra Beli7Vijay K. Tiwari8Institute of Molecular Biology (IMB)Institute of Physiological Chemistry, University Medical Center, Johannes Gutenberg UniversityInstitute of Molecular Biology (IMB)Institute of Molecular Biology (IMB)Institute of Molecular Biology (IMB)TRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbHDepartment of Internal Medicine I, University Medical Center, Johannes Gutenberg UniversityInstitute of Molecular Biology (IMB)Institute of Molecular Biology (IMB)Epithelial-to-mesenchymal transition (EMT) regulates both processes of organism development and changes in cell state causing disease. Here, the authors show that an E3 ubiquitin ligase, FBXO32, regulates EMT via CtBP1 and the transcriptional program, and also mediates cancer metastatic burden and neurogenesis.https://doi.org/10.1038/s41467-017-01366-x
collection DOAJ
language English
format Article
sources DOAJ
author Sanjeeb Kumar Sahu
Neha Tiwari
Abhijeet Pataskar
Yuan Zhuang
Marina Borisova
Mustafa Diken
Susanne Strand
Petra Beli
Vijay K. Tiwari
spellingShingle Sanjeeb Kumar Sahu
Neha Tiwari
Abhijeet Pataskar
Yuan Zhuang
Marina Borisova
Mustafa Diken
Susanne Strand
Petra Beli
Vijay K. Tiwari
FBXO32 promotes microenvironment underlying epithelial-mesenchymal transition via CtBP1 during tumour metastasis and brain development
Nature Communications
author_facet Sanjeeb Kumar Sahu
Neha Tiwari
Abhijeet Pataskar
Yuan Zhuang
Marina Borisova
Mustafa Diken
Susanne Strand
Petra Beli
Vijay K. Tiwari
author_sort Sanjeeb Kumar Sahu
title FBXO32 promotes microenvironment underlying epithelial-mesenchymal transition via CtBP1 during tumour metastasis and brain development
title_short FBXO32 promotes microenvironment underlying epithelial-mesenchymal transition via CtBP1 during tumour metastasis and brain development
title_full FBXO32 promotes microenvironment underlying epithelial-mesenchymal transition via CtBP1 during tumour metastasis and brain development
title_fullStr FBXO32 promotes microenvironment underlying epithelial-mesenchymal transition via CtBP1 during tumour metastasis and brain development
title_full_unstemmed FBXO32 promotes microenvironment underlying epithelial-mesenchymal transition via CtBP1 during tumour metastasis and brain development
title_sort fbxo32 promotes microenvironment underlying epithelial-mesenchymal transition via ctbp1 during tumour metastasis and brain development
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-11-01
description Epithelial-to-mesenchymal transition (EMT) regulates both processes of organism development and changes in cell state causing disease. Here, the authors show that an E3 ubiquitin ligase, FBXO32, regulates EMT via CtBP1 and the transcriptional program, and also mediates cancer metastatic burden and neurogenesis.
url https://doi.org/10.1038/s41467-017-01366-x
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