Independent Negative Prognostic Role of TCF1 Expression within the Wnt/β-Catenin Signaling Pathway in Primary Breast Cancer Patients

Independent Negative Prognostic Role of TCF1 Expression within the Wnt/β-Catenin Signaling Pathway in Primary Breast Cancer Patients

The Wnt pathway is involved in the progression of breast cancer (BC). We aimed to evaluate the expression of some components of the Wnt pathway (β-catenin, FZD4 (frizzled receptor 4), LRP5 (low-density lipoprotein receptor-related protein 5), LRP6, and TCF1 (T-cell factor 1)) to detect pote...

Full description

Bibliographic Details
Main Authors:	Concetta Saponaro, Emanuela Scarpi, Francesco Alfredo Zito, Francesco Giotta, Nicola Silvestris, Anita Mangia
Format:	Article
Language:	English
Published:	MDPI AG 2019-07-01
Series:	Cancers
Subjects:	Breast Cancer Wnt pathway TCF1 NHERF1
Online Access:	https://www.mdpi.com/2072-6694/11/7/1035

Similar Items

NHERF1 and tumor microenvironment: a new scene in invasive breast carcinoma
by: Concetta Saponaro, et al.
Published: (2018-05-01)

Wnt1 Positively Regulates CD36 Expression via TCF4 and PPAR-γ in Macrophages
by: Shuai Wang, et al.
Published: (2015-02-01)

Tcf7L2 is essential for neurogenesis in the developing mouse neocortex
by: Olga Chodelkova, et al.
Published: (2018-05-01)

A Single TCF Transcription Factor, Regardless of Its Activation Capacity, Is Sufficient for Effective Trilineage Differentiation of ESCs
by: Steven Moreira, et al.
Published: (2017-09-01)

Diverse LEF/TCF Expression in Human Colorectal Cancer Correlates with Altered Wnt-Regulated Transcriptome in a Meta-Analysis of Patient Biopsies
by: Claus-Dieter Mayer, et al.
Published: (2020-05-01)

Silencing of the Wnt transcription factor TCF4 sensitizes colorectal cancer cells to (chemo-) radiotherapy
by: Kendziorra, Emil Fritz
Published: (2014)

The involvement of the wnt signaling pathway and TCF7L2 in diabetes mellitus: The current understanding, dispute, and perspective
by: Ip Wilfred, et al.
Published: (2012-08-01)

Peritumoral vascular invasion and NHERF1 expression define an immunophenotype of grade 2 invasive breast cancer associated with poor prognosis
by: Malfettone Andrea, et al.
Published: (2012-03-01)

Wnt Effector TCF4 Is Dispensable for Wnt Signaling in Human Cancer Cells
by: Dusan Hrckulak, et al.
Published: (2018-09-01)

FOXP3 promotes tumor growth and metastasis by activating Wnt/β-catenin signaling pathway and EMT in non-small cell lung cancer
by: Shucai Yang, et al.
Published: (2017-07-01)

The β-catenin/TCF-4 pathway regulates the expression of OPN in human osteoarthritic chondrocytes
by: Jian Tian, et al.
Published: (2020-08-01)

Novel roles for TCF-1 and LEF-1 in directing CD4+ T cell fate and silencing CD4 in CD8+ T cells
by: Steinke, Farrah Christine
Published: (2015)

TCF7L2 silencing results in altered gene expression patterns accompanied by local genomic reorganization
by: Markus A. Brown, et al.
Published: (2021-02-01)

miR-139-5p functions as a tumor suppressor in cervical cancer by targeting TCF4 and inhibiting Wnt/β-catenin signaling
by: Ji X, et al.
Published: (2019-09-01)

The Transcription Factor TCF1 in T Cell Differentiation and Aging
by: Chulwoo Kim, et al.
Published: (2020-09-01)

Inflammation and Wnt Signaling: Target for Immunomodulatory Therapy?
by: Imen Jridi, et al.
Published: (2021-02-01)

The expression of dominant negative TCF7L2 in pancreatic beta cells during the embryonic stage causes impaired glucose homeostasis
by: Weijuan Shao, et al.
Published: (2015-04-01)

Wnt-11 signalling, its role in cardiogenesis and identification of Wnt/β-catenin pathway target genes
by: Railo, A. (Antti)
Published: (2010)

<i>miR-7</i> Controls the Dopaminergic/Oligodendroglial Fate through Wnt/β-catenin Signaling Regulation
by: Lavanya Adusumilli, et al.
Published: (2020-03-01)

The role of the Wnt signaling pathway in incretin hormone production and function
by: Yu-ting Alex Chiang, et al.
Published: (2012-07-01)

A β-catenin-driven switch in TCF/LEF transcription factor binding to DNA target sites promotes commitment of mammalian nephron progenitor cells
by: Qiuyu Guo, et al.
Published: (2021-02-01)

Nuclear Regulation of Wnt/β-Catenin Signaling: It’s a Complex Situation
by: Christin C. Anthony, et al.
Published: (2020-08-01)

Enhancement of plant cold tolerance by soybean RCC1 family gene GmTCF1a
by: Zhanghui Dong, et al.
Published: (2021-08-01)

FOXM 1 induces Vasculogenic mimicry in esophageal cancer through β-catenin /Tcf4 signaling
by: Lili Cheng, et al.
Published: (2020-02-01)

MiR-452 promotes an aggressive colorectal cancer phenotype by regulating a Wnt/β-catenin positive feedback loop
by: Tingting Li, et al.
Published: (2018-09-01)

Phosphorylation of Shrimp Tcf by a Viral Protein Kinase WSV083 Suppresses Its Antiviral Effect
by: Chuanqi Wang, et al.
Published: (2021-08-01)

LncRNA MIR194-2HG Promotes Cell Proliferation and Metastasis via Regulation of miR-1207-5p/TCF19/Wnt/β-Catenin Signaling in Liver Cancer
by: Xu G, et al.
Published: (2020-10-01)

NHERF1 Enhances Cisplatin Sensitivity in Human Cervical Cancer Cells
by: Tao Tao, et al.
Published: (2017-01-01)

The Wnt Signaling Pathway Effector TCF7L2 Mediates Olanzapine-Induced Weight Gain and Insulin Resistance
by: Ranran Li, et al.
Published: (2018-04-01)

Novel β-catenin target genes identified in thalamic neurons encode modulators of neuronal excitability
by: Wisniewska Marta B, et al.
Published: (2012-11-01)

TCF7L1 promotes skin tumorigenesis independently of β-catenin through induction of LCN2
by: Amy T Ku, et al.
Published: (2017-05-01)

A Shared Regulatory Element Controls the Initiation of Tcf7 Expression During Early T Cell and Innate Lymphoid Cell Developments
by: Christelle Harly, et al.
Published: (2020-03-01)

TCF/LEF regulation of the topologically associated domain ADI promotes mESCs to exit the pluripotent ground state
by: Nikolaos Doumpas, et al.
Published: (2021-09-01)

HPV-18 E6 Oncoprotein and Its Spliced Isoform E6*I Regulate the Wnt/β-Catenin Cell Signaling Pathway through the TCF-4 Transcriptional Factor
by: J. Omar Muñoz-Bello, et al.
Published: (2018-10-01)

Variations in the Wnt/β-Catenin Pathway Key Genes as Predictors of Cervical Cancer Susceptibility
by: Wang B, et al.
Published: (2020-05-01)

The Hedgehog Inhibitor Cyclopamine Reduces β-Catenin-Tcf Transcriptional Activity, Induces E-Cadherin Expression, and Reduces Invasion in Colorectal Cancer Cells
by: David Qualtrough, et al.
Published: (2015-09-01)

Variations in the Wnt/β-Catenin Pathway Key Genes as Predictors of Cervical Cancer Susceptibility [Corrigendum]
by: Wang B, et al.
Published: (2020-08-01)

Protein-DNA Interactions at the Opossum Npt2a Promoter are Dependent upon NHERF-1
by: Barbara J. Clark, et al.
Published: (2016-06-01)

The Role of the C-Clamp in Wnt-Related Colorectal Cancers
by: Aditi J. Ravindranath, et al.
Published: (2016-08-01)

Roles of β-catenin, TCF-4, and survivin in nasopharyngeal carcinoma: correlation with clinicopathological features and prognostic significance
by: Pei-Ying Jin, et al.
Published: (2019-02-01)