Oncogenic KRas-induced Increase in Fluid-phase Endocytosis is Dependent on N-WASP and is Required for the Formation of Pancreatic Preneoplastic Lesions

Oncogenic KRas-induced Increase in Fluid-phase Endocytosis is Dependent on N-WASP and is Required for the Formation of Pancreatic Preneoplastic Lesions

Fluid-phase endocytosis is a homeostatic process with an unknown role in tumor initiation. The driver mutation in pancreatic ductal adenocarcinoma (PDAC) is constitutively active KRasG12D, which induces neoplastic transformation of acinar cells through acinar-to-ductal metaplasia (ADM). We have prev...

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Bibliographic Details
Main Authors: Clara Lubeseder-Martellato, Katharina Alexandrow, Ana Hidalgo-Sastre, Irina Heid, Sophie Luise Boos, Thomas Briel, Roland M. Schmid, Jens T. Siveke
Format: Article
Language:English
Published: Elsevier 2017-02-01
Series:EBioMedicine
Subjects:
Oncogenic KRas
Fluid-phase endocytosis
Pancreatic ductal adenocarcinoma (PDAC)
Acinar-to-ductal metaplasia (ADM)
Acinar epithelial explants
Neural-Wiskott-Aldrich syndrome protein (N-WASP)
Mice models
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396416305928

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