Efficient generation of myostatin (MSTN) biallelic mutations in cattle using zinc finger nucleases.

Efficient generation of myostatin (MSTN) biallelic mutations in cattle using zinc finger nucleases.

Genetically engineered zinc-finger nucleases (ZFNs) are useful for marker-free gene targeting using a one-step approach. We used ZFNs to efficiently disrupt bovine myostatin (MSTN), which was identified previously as the gene responsible for double muscling in cattle. The mutation efficiency of bovi...

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Bibliographic Details
Main Authors: Junjie Luo, Zhiyuan Song, Shengli Yu, Dan Cui, Benli Wang, Fangrong Ding, Song Li, Yunping Dai, Ning Li
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3990601?pdf=render

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