Investigations of Structural Requirements for BRD4 Inhibitors through Ligand- and Structure-Based 3D QSAR Approaches

Investigations of Structural Requirements for BRD4 Inhibitors through Ligand- and Structure-Based 3D QSAR Approaches

The bromodomain containing protein 4 (BRD4) recognizes acetylated histone proteins and plays numerous roles in the progression of a wide range of cancers, due to which it is under intense investigation as a novel anti-cancer drug target. In the present study, we performed three-dimensional quantitat...

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Bibliographic Details
Main Authors: Adeena Tahir, Rima D. Alharthy, Saadia Naseem, Natasha Mahmood, Mahmood Ahmed, Khuram Shahzad, Malik Nadeem Akhtar, Abdul Hameed, Irfan Sadiq, Haq Nawaz, Muhammad Muddassar
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:Molecules
Subjects:
BRD4 protein inhibitors
molecular docking
3D-QSAR
CoMFA
CoMSIA
Online Access:http://www.mdpi.com/1420-3049/23/7/1527

Internet

http://www.mdpi.com/1420-3049/23/7/1527

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