Epigenome Chaos: Stochastic and Deterministic DNA Methylation Events Drive Cancer Evolution

Epigenome Chaos: Stochastic and Deterministic DNA Methylation Events Drive Cancer Evolution

Cancer evolution is associated with genomic instability and epigenetic alterations, which contribute to the inter and intra tumor heterogeneity, making genetic markers not accurate to monitor tumor evolution. Epigenetic changes, aberrant DNA methylation and modifications of chromatin proteins, deter...

Full description

Bibliographic Details
Main Authors:	Giusi Russo, Alfonso Tramontano, Ilaria Iodice, Lorenzo Chiariotti, Antonio Pezone
Format:	Article
Language:	English
Published:	MDPI AG 2021-04-01
Series:	Cancers
Subjects:	genomic instability epigenetic alterations clonal expansion clonal selection genome and epigenome chaos cancer evolution
Online Access:	https://www.mdpi.com/2072-6694/13/8/1800

Similar Items

The Genomic Processes of Biological Invasions: From Invasive Species to Cancer Metastases and Back Again
by: Fargam Neinavaie, et al.
Published: (2021-09-01)

New Insights in the Cytogenetic Practice: Karyotypic Chaos, Non-Clonal Chromosomal Alterations and Chromosomal Instability in Human Cancer and Therapy Response
by: Nelson Rangel, et al.
Published: (2017-06-01)

Genomic-Destabilization-Associated Mutagenesis and Clonal Evolution of Cells with Mutations in Tumor-Suppressor Genes
by: Ken-ichi Yoshioka, et al.
Published: (2019-10-01)

Chromosomal Instability in Farmers Exposed to Pesticides: High Prevalence of Clonal and Non-Clonal Chromosomal Alterations
by: Cepeda S, et al.
Published: (2020-02-01)

Micronuclei and Genome Chaos: Changing the System Inheritance
by: Christine J. Ye, et al.
Published: (2019-05-01)

Frontiers in Toxicogenomics – the grand challenge: to understand how the genome and epigenome interact with the toxic environment
by: Douglas Mark Ruden
Published: (2011-03-01)

Deciphering and manipulating the epigenome for the treatment of Parkinson’s and Alzheimer’s disease
by: Chidiebere Emmanuel Okechukwu
Published: (2021-01-01)

Manipulating the Epigenome in Nuclear Transfer Cloning: Where, When and How
by: Kilian Simmet, et al.
Published: (2021-12-01)

Deconvolution of the Genomic and Epigenomic Interaction Landscape of Triple-Negative Breast Cancer
by: Jiande Wu, et al.
Published: (2019-10-01)

Enhanced JBrowse plugins for epigenomics data visualization
by: Brigitte T. Hofmeister, et al.
Published: (2018-04-01)

Characterization of Altered Enhancer Usage Across the Human Colorectal Cancer Epigenome
by: Cohen, Andrea
Published: (2017)

Epigenome engineering in cancer: fairytale or a realistic path to the clinic?
by: Fahimeh eFalahi, et al.
Published: (2015-02-01)

Genomic and Transcriptomic Landscape of Tumor Clonal Evolution in Cholangiocarcinoma
by: Geng Chen, et al.
Published: (2020-03-01)

Tracing cellular heterogeneity in pooled genetic screens via multi-level barcoding
by: Michael Boettcher, et al.
Published: (2019-02-01)

Molecular biology and riddle of cancer: the ‘Tom & Jerry’ show
by: Md. Al Mamun, et al.
Published: (2011-11-01)

Pseudomonas aeruginosa genomic structure and diversity
by: Jens eKlockgether, et al.
Published: (2011-07-01)

Nonclonal chromosomal alterations and poor survival in cytopenic patients without hematological malignancies
by: Osamu Imataki, et al.
Published: (2019-11-01)

Streptococcus agalactiae Sequence Type 283 in Farmed Fish, Brazil
by: Carlos A.G. Leal, et al.
Published: (2019-04-01)

Modeling population size independent tissue epigenomes by ChIL-seq with single thin sections
by: Fukuoka, M., et al.
Published: (2021)

Habit acquisition in the context of neuronal genomic and epigenomic mosaicism
by: Francisco Javier Novo
Published: (2014-04-01)

Measuring Intratumoral Heterogeneity of Immune Repertoires
by: Diana Vladimirovna Yuzhakova, et al.
Published: (2020-05-01)

Editorial: Genomics and Epigenomics of Cancer Immunotherapy: Challenges and Clinical Implications
by: Malak Abedalthagafi
Published: (2021-07-01)

Prader-Willi Syndrome: The Disease that Opened up Epigenomic-Based Preemptive Medicine
by: Takeo Kubota, et al.
Published: (2016-03-01)

Transcriptome of Russet Norkotah and its clonal selection, TXNS278
by: Julien Levy, et al.
Published: (2018-03-01)

PCIP-seq: simultaneous sequencing of integrated viral genomes and their insertion sites with long reads
by: Maria Artesi, et al.
Published: (2021-04-01)

Mitochondrion at the Crossroad Between Nutrients and Epigenome
by: Giusi Taormina, et al.
Published: (2019-10-01)

Combined deletion of Xrcc4 and Trp53 in mouse germinal center B cells leads to novel B cell lymphomas with clonal heterogeneity
by: Zhangguo Chen, et al.
Published: (2016-01-01)

Multi-target analysis of neoplasms for the evaluation of tumor progression: stochastic approach of biologic processes
by: Fatima Al-Hashimi, et al.
Published: (2018-01-01)

Abitudini ed ereditarietà: la rivincita di Lamarck?
by: Alessandro Capitanini, et al.
Published: (2021-07-01)

Leveraging Genomics, Transcriptomics, and Epigenomics to Understand the Biology and Chemoresistance of Ovarian Cancer
by: Sandra Muñoz-Galván, et al.
Published: (2021-08-01)

Crescimento de mudas e produtividade de minijardins clonais de eucalipto tratados com rizobactérias selecionadas Growth of cuttings and productivity of mini - clonal hedges, treated with selected rhizobacteria
by: Reginaldo Gonçalves Mafia, et al.
Published: (2005-12-01)

Enxertia in vitro na propagação de clones de Eucalyptus urophylla e E. grandis In vitro grafting in the propagation of Eucalyptus urophylla and E. grandis clones
by: Fabiana Schmidt Bandeira, et al.
Published: (2006-02-01)

Clone History Shapes the Populus Drought Transcriptome
by: Raj, Sherosha Joan Sharmila
Published: (2009)

Clone History Shapes the Populus Drought Transcriptome
by: Raj, Sherosha Joan Sharmila
Published: (2009)

The genomic landscape of teenage and young adult T‐cell acute lymphoblastic leukemia
by: Marcela B. Mansur, et al.
Published: (2021-07-01)

Population Genomics and Phylogeography of a Clonal Bryophyte With Spatially Separated Sexes and Extreme Sex Ratios
by: Marta Alonso-García, et al.
Published: (2020-05-01)

Distinct Phenotypic and Genomic Signatures Underlie Contrasting Pathogenic Potential of Staphylococcus epidermidis Clonal Lineages
by: Diana Espadinha, et al.
Published: (2019-08-01)

Phylogenomic analyses confirm a novel invasive North American Corbicula (Bivalvia: Cyrenidae) lineage
by: Amanda E. Haponski, et al.
Published: (2019-08-01)

Investigating a rare methicillin-resistant Staphylococcus aureus strain: first description of genome sequencing and molecular characterization of CC15-MRSA
by: Senok AC, et al.
Published: (2017-10-01)

A study of elective genome sequencing and pharmacogenetic testing in an unselected population
by: Meagan Cochran, et al.
Published: (2021-09-01)