LMWF5A suppresses cytokine release by modulating select inflammatory transcription factor activity in stimulated PBMC

LMWF5A suppresses cytokine release by modulating select inflammatory transcription factor activity in stimulated PBMC

Abstract Background Dysregulation of transcription and cytokine expression has been implicated in the pathogenesis of a variety inflammatory diseases. The resulting imbalance between inflammatory and resolving transcriptional programs can cause an overabundance of pro-inflammatory, classically activ...

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Bibliographic Details
Main Authors: Gregory Thomas, Elizabeth Frederick, Lisa Thompson, Raphael Bar-Or, Yetti Mulugeta, Melissa Hausburg, Michael Roshon, Charles Mains, David Bar-Or
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Journal of Translational Medicine
Subjects:
LMWF5A
PPARγ
AhR
NF-κb
STAT
Transcription
Online Access:https://doi.org/10.1186/s12967-020-02626-z

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