Evaluation of Deltamethrin induced reproductive toxicity in male Swiss Albino mice

• Main Authors: Ketaki R. Desai, Nilofer Moid, Pragnesh B. Patel, Hyacinth N. Highland
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2016-03-01
• Series: Asian Pacific Journal of Reproduction
• Subjects: Deltamethrin; Male mice; Testis; Reproductive toxicity
• Online Access: http://www.sciencedirect.com/science/article/pii/S2305050015000548

Objective: To assess the adverse effect of Deltamethrin (DM) (technical grade) on reproductive organs and fertility indices of male Swiss albino mice, Mus musculus. Methods: Forty male mice were divided into four experimental groups: control, vehicle control (peanut oil), high dose DM treated and low dose DM treated group. An oral dose of 3 mg/kg b.wt (low dose) and 6 mg/kg b.wt (high dose) of Deltamethrin was administered for a period of 45 days to male Swiss albino mice. Results: DM caused a significant reduction in body and organ weights, sperm count, sperm motility percent, sperm viability, serum testosterone level, sialic acid content of cauda epididymis and fructose level of seminal vesicle. DM-treated groups also showed a significant decline in testicular 3β and 17β Hydroxysteroid Dehydrogenase (HSD) activities. Histological examinations revealed significant alterations in the testes of dosed groups. Conclusion: Deltamethrin is a toxic pyrethroid pesticide that produced significant reproductive toxicity in treated male mice as revealed by the severely affected parameters and the altered gravimetric indices.