Epigenetic prediction of 17β-estradiol and relationship to trauma-related outcomes in women

Epigenetic prediction of 17β-estradiol and relationship to trauma-related outcomes in women

17β-estradiol (E2) levels in women correlate with multiple neuropsychiatric symptoms, including those that are stress-related. Furthermore, prior work from our group has demonstrated that E2 status influences DNA methylation (DNAm) across the genome. We developed and validated a DNAm-based predictor...

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Bibliographic Details
Main Authors: Laura M. Hack, Shota Nishitani, Anna K. Knight, Varun Kilaru, Stephanie A. Maddox, Antonia V. Seligowski, Tanja Jovanovic, Kerry J. Ressler, Alicia K. Smith, Vasiliki Michopoulos
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Comprehensive Psychoneuroendocrinology
Subjects:
DNA methylation
Estrogen
Random forests (RFs)
Machine learning
Biomarker
Trauma
Online Access:http://www.sciencedirect.com/science/article/pii/S2666497621000199

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