Increased Non-Homologous End Joining Makes DNA-PK a Promising Target for Therapeutic Intervention in Uveal Melanoma

Increased Non-Homologous End Joining Makes DNA-PK a Promising Target for Therapeutic Intervention in Uveal Melanoma

Uveal melanoma (UM) is the most common primary intraocular tumour in adults, with a mean survival of six months following metastasis. The survival rates have not improved in over 30 years. This study has shown that sister chromatid exchange (SCE) is low in UM which is likely due to a reduced express...

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Bibliographic Details
Main Authors: Rachel E. Doherty, Helen E. Bryant, Manoj K. Valluru, Ian G. Rennie, Karen Sisley
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Cancers
Subjects:
uveal melanoma
DNA-PK
NHEJ
HR
PARP
chemo-sensitization
Online Access:https://www.mdpi.com/2072-6694/11/9/1278

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