Expressing a cytosolic pyruvate dehydrogenase complex to increase free fatty acid production in Saccharomyces cerevisiae

Abstract Background Saccharomyces cerevisiae is being exploited as a cell factory to produce fatty acids and their derivatives as biofuels. Previous studies found that both precursor supply and fatty acid metabolism deregulation are essential for enhanced fatty acid synthesis. A bacterial pyruvate d...

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Bibliographic Details
Main Authors: Yiming Zhang, Mo Su, Ning Qin, Jens Nielsen, Zihe Liu
Format: Article
Language:English
Published: BMC 2020-12-01
Series:Microbial Cell Factories
Subjects:
Online Access:https://doi.org/10.1186/s12934-020-01493-z