Parallel Evolution of High-Level Aminoglycoside Resistance in Escherichia coli Under Low and High Mutation Supply Rates

Parallel Evolution of High-Level Aminoglycoside Resistance in Escherichia coli Under Low and High Mutation Supply Rates

Antibiotic resistance is a major concern in public health worldwide, thus there is much interest in characterizing the mutational pathways through which susceptible bacteria evolve resistance. Here we use experimental evolution to explore the mutational pathways toward aminoglycoside resistance, usi...

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Bibliographic Details
Main Authors: Claudia Ibacache-Quiroga, Juan C. Oliveros, Alejandro Couce, Jesus Blázquez
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Microbiology
Subjects:
antibiotic resistance
evolution
mutation rate
aminoglycosides
Escherichia coli
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2018.00427/full

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