Next-generation sequencing refines the genetic architecture of Greek GnRH-deficient patients

Next-generation sequencing refines the genetic architecture of Greek GnRH-deficient patients

Isolated gonadotropin-releasing hormone (GnRH) deficiency (IGD) is a rare disease with a wide spectrum of reproductive and non-reproductive clinical characteristics. Apart from the phenotypic heterogeneity, IGD is also highly genetically heterogeneous with >35 genes implicated in the disease. Des...

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Bibliographic Details
Main Authors: M I Stamou, P Varnavas, L Plummer, V Koika, N A Georgopoulos
Format: Article
Language:English
Published: Bioscientifica 2019-04-01
Series:Endocrine Connections
Subjects:
GnRH
genetics
whole exome sequencing
Kallmann
hypogonadism
Online Access:https://ec.bioscientifica.com/view/journals/ec/8/5/EC-19-0010.xml

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