Trauma-induced regulation of VHP-1 modulates the cellular response to mechanical stress

The nervous system utilizes adaptive strategies to mitigate trauma-induced neurodegeneration. Here, the authors report that a MAPK phosphatase VHP-1 is induced by trauma and regulates transcriptional responses to mechanical stress in a C. elegans model.

Bibliographic Details
Main Authors:	Nathan Egge, Sonja L. B. Arneaud, Rene Solano Fonseca, Kielen R. Zuurbier, Jacob McClendon, Peter M. Douglas
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-03-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-21611-8

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spelling	doaj-ff44cb20fe82453182d0e975c52b4f952021-03-11T11:32:18ZengNature Publishing GroupNature Communications2041-17232021-03-0112111810.1038/s41467-021-21611-8Trauma-induced regulation of VHP-1 modulates the cellular response to mechanical stressNathan Egge0Sonja L. B. Arneaud1Rene Solano Fonseca2Kielen R. Zuurbier3Jacob McClendon4Peter M. Douglas5Department of Molecular Biology, UT Southwestern Medical CenterDepartment of Molecular Biology, UT Southwestern Medical CenterDepartment of Molecular Biology, UT Southwestern Medical CenterDepartment of Molecular Biology, UT Southwestern Medical CenterDepartment of Molecular Biology, UT Southwestern Medical CenterDepartment of Molecular Biology, UT Southwestern Medical CenterThe nervous system utilizes adaptive strategies to mitigate trauma-induced neurodegeneration. Here, the authors report that a MAPK phosphatase VHP-1 is induced by trauma and regulates transcriptional responses to mechanical stress in a C. elegans model.https://doi.org/10.1038/s41467-021-21611-8
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Nathan Egge Sonja L. B. Arneaud Rene Solano Fonseca Kielen R. Zuurbier Jacob McClendon Peter M. Douglas
spellingShingle	Nathan Egge Sonja L. B. Arneaud Rene Solano Fonseca Kielen R. Zuurbier Jacob McClendon Peter M. Douglas Trauma-induced regulation of VHP-1 modulates the cellular response to mechanical stress Nature Communications
author_facet	Nathan Egge Sonja L. B. Arneaud Rene Solano Fonseca Kielen R. Zuurbier Jacob McClendon Peter M. Douglas
author_sort	Nathan Egge
title	Trauma-induced regulation of VHP-1 modulates the cellular response to mechanical stress
title_short	Trauma-induced regulation of VHP-1 modulates the cellular response to mechanical stress
title_full	Trauma-induced regulation of VHP-1 modulates the cellular response to mechanical stress
title_fullStr	Trauma-induced regulation of VHP-1 modulates the cellular response to mechanical stress
title_full_unstemmed	Trauma-induced regulation of VHP-1 modulates the cellular response to mechanical stress
title_sort	trauma-induced regulation of vhp-1 modulates the cellular response to mechanical stress
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-03-01
description	The nervous system utilizes adaptive strategies to mitigate trauma-induced neurodegeneration. Here, the authors report that a MAPK phosphatase VHP-1 is induced by trauma and regulates transcriptional responses to mechanical stress in a C. elegans model.
url	https://doi.org/10.1038/s41467-021-21611-8
work_keys_str_mv	AT nathanegge traumainducedregulationofvhp1modulatesthecellularresponsetomechanicalstress AT sonjalbarneaud traumainducedregulationofvhp1modulatesthecellularresponsetomechanicalstress AT renesolanofonseca traumainducedregulationofvhp1modulatesthecellularresponsetomechanicalstress AT kielenrzuurbier traumainducedregulationofvhp1modulatesthecellularresponsetomechanicalstress AT jacobmcclendon traumainducedregulationofvhp1modulatesthecellularresponsetomechanicalstress AT petermdouglas traumainducedregulationofvhp1modulatesthecellularresponsetomechanicalstress
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Trauma-induced regulation of VHP-1 modulates the cellular response to mechanical stress

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