mTOR inhibition by everolimus in childhood acute lymphoblastic leukemia induces caspase-independent cell death.

mTOR inhibition by everolimus in childhood acute lymphoblastic leukemia induces caspase-independent cell death.

Increasingly, anti-cancer medications are being reported to induce cell death mechanisms other than apoptosis. Activating alternate death mechanisms introduces the potential to kill cells that have defects in their apoptotic machinery, as is commonly observed in cancer cells, including in hematologi...

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Bibliographic Details
Main Authors: Rana Baraz, Adam Cisterne, Philip O Saunders, John Hewson, Marilyn Thien, Jocelyn Weiss, Jordan Basnett, Kenneth F Bradstock, Linda J Bendall
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4094511?pdf=render

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