Dynamic thiol/disulfide homeostasis and oxidant status in patients with hypoparathyroidism

• Main Authors: Or Koca Arzu, Dağdeviren Murat, Akkan Tolga, Ateş İhsan, Neşelioğlu Salim, Erel Özcan, Altay Mustafa
• Format: Article
• Language: English
• Published: Society of Medical Biochemists of Serbia, Belgrade 2020-01-01
• Series: Journal of Medical Biochemistry
• Subjects: hypoparathyroidism; total oxidant status; total antioxidant status; disulfide; thiol; paraoxonase
• Online Access: https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2020/1452-82582002231O.pdf
• ISSN: 1452-8258; 1452-8266

Background: In this study, we aimed at determining the dynamic thiol/disulfide homeostasis and oxidant balance, and investigating the relation of these parameters to the severity of the disease and the serum calcium levels. Methods: 55 patients with iatrogenic hypoparathyroidism follow-ups and 40 healthy volunteers were included in the study. The blood dynamic thiol/sulfide balance, Total Antioxidant Status (TAS), Total Oxidant Status (TOS), Paraoxonase Enzyme Activity (PON) levels were measured in serum samples. Results: In our study, it was found that the disulfide, disulfide/native thiol, disulfide/total thiol levels were higher in the hypoparathyroidism group. A negative correlation was found between 25-hydroxy vitamin D (25-OH vitamin D) and disulfide, disulfide/native thiol and disulfide/total thiol, and a positive correlation was found between native thiol and total thiol ratio; and the corrected calcium levels and PON levels were negatively correlated. Conclusions: Consequently, a change in favour of disulfide was found in the dynamic thiol-disulfide homeostasis in the hypoparathyroidism group in our study.