The need for fast-track, high-quality and low-cost studies about the role of the BCG vaccine in the fight against COVID-19

The need for fast-track, high-quality and low-cost studies about the role of the BCG vaccine in the fight against COVID-19

Abstract Bacillus Calmette-Guérin (BCG) vaccination is routine and near-universal in many low- and middle-income countries (LMIC). It has been suggested that BCG can have a protective effect on COVID-19 morbidity and mortality. This commentary discusses the limitations of the evidence around BCG and...

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Main Authors: Marcos Pereira, Enny Paixão, Anete Trajman, Ramon Andrade de Souza, Marcio Santos da Natividade, Julia M. Pescarini, Susan Martins Pereira, Florisneide Rodrigues Barreto, Ricardo Ximenes, Margareth Dalcomo, Maria Yury Ichihara, Ceuci Nunes, Manoel Barral-Netto, Maurício L. Barreto
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Respiratory Research
Online Access:http://link.springer.com/article/10.1186/s12931-020-01439-4
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spelling doaj-ff287f32e1f1408ead209f344ef6f6f32020-11-25T03:29:07ZengBMCRespiratory Research1465-993X2020-07-012111310.1186/s12931-020-01439-4The need for fast-track, high-quality and low-cost studies about the role of the BCG vaccine in the fight against COVID-19Marcos Pereira0Enny Paixão1Anete Trajman2Ramon Andrade de Souza3Marcio Santos da Natividade4Julia M. Pescarini5Susan Martins Pereira6Florisneide Rodrigues Barreto7Ricardo Ximenes8Margareth Dalcomo9Maria Yury Ichihara10Ceuci Nunes11Manoel Barral-Netto12Maurício L. Barreto13Institute of Collective Health, Federal University of BahiaCenter for Data and Knowledge Integration for Health (CIDACS)Instituto de Medicina Social, Universidade do Estado do Rio de JaneiroInstitute of Collective Health, Federal University of BahiaInstitute of Collective Health, Federal University of BahiaCenter for Data and Knowledge Integration for Health (CIDACS)Institute of Collective Health, Federal University of BahiaInstitute of Collective Health, Federal University of BahiaDepartamento de Medicina Tropical, Universidade Federal de PernambucoCentro de Referência Hélio Fraga, Fundação Oswaldo CruzCenter for Data and Knowledge Integration for Health (CIDACS)Hospital Couto Maia, Secretaria Estadual de Saúde da BahiaInstituto Gonçalo Moniz - Fundação Oswaldo Cruz (Fiocruz)Institute of Collective Health, Federal University of BahiaAbstract Bacillus Calmette-Guérin (BCG) vaccination is routine and near-universal in many low- and middle-income countries (LMIC). It has been suggested that BCG can have a protective effect on COVID-19 morbidity and mortality. This commentary discusses the limitations of the evidence around BCG and COVID-19. We argue that higher-quality evidence is necessary to understand the protective effect of the BCG vaccine from existing, secondary data, while we await results from clinical trials currently conducted in different settings.http://link.springer.com/article/10.1186/s12931-020-01439-4
collection DOAJ
language English
format Article
sources DOAJ
author Marcos Pereira
Enny Paixão
Anete Trajman
Ramon Andrade de Souza
Marcio Santos da Natividade
Julia M. Pescarini
Susan Martins Pereira
Florisneide Rodrigues Barreto
Ricardo Ximenes
Margareth Dalcomo
Maria Yury Ichihara
Ceuci Nunes
Manoel Barral-Netto
Maurício L. Barreto
spellingShingle Marcos Pereira
Enny Paixão
Anete Trajman
Ramon Andrade de Souza
Marcio Santos da Natividade
Julia M. Pescarini
Susan Martins Pereira
Florisneide Rodrigues Barreto
Ricardo Ximenes
Margareth Dalcomo
Maria Yury Ichihara
Ceuci Nunes
Manoel Barral-Netto
Maurício L. Barreto
The need for fast-track, high-quality and low-cost studies about the role of the BCG vaccine in the fight against COVID-19
Respiratory Research
author_facet Marcos Pereira
Enny Paixão
Anete Trajman
Ramon Andrade de Souza
Marcio Santos da Natividade
Julia M. Pescarini
Susan Martins Pereira
Florisneide Rodrigues Barreto
Ricardo Ximenes
Margareth Dalcomo
Maria Yury Ichihara
Ceuci Nunes
Manoel Barral-Netto
Maurício L. Barreto
author_sort Marcos Pereira
title The need for fast-track, high-quality and low-cost studies about the role of the BCG vaccine in the fight against COVID-19
title_short The need for fast-track, high-quality and low-cost studies about the role of the BCG vaccine in the fight against COVID-19
title_full The need for fast-track, high-quality and low-cost studies about the role of the BCG vaccine in the fight against COVID-19
title_fullStr The need for fast-track, high-quality and low-cost studies about the role of the BCG vaccine in the fight against COVID-19
title_full_unstemmed The need for fast-track, high-quality and low-cost studies about the role of the BCG vaccine in the fight against COVID-19
title_sort need for fast-track, high-quality and low-cost studies about the role of the bcg vaccine in the fight against covid-19
publisher BMC
series Respiratory Research
issn 1465-993X
publishDate 2020-07-01
description Abstract Bacillus Calmette-Guérin (BCG) vaccination is routine and near-universal in many low- and middle-income countries (LMIC). It has been suggested that BCG can have a protective effect on COVID-19 morbidity and mortality. This commentary discusses the limitations of the evidence around BCG and COVID-19. We argue that higher-quality evidence is necessary to understand the protective effect of the BCG vaccine from existing, secondary data, while we await results from clinical trials currently conducted in different settings.
url http://link.springer.com/article/10.1186/s12931-020-01439-4
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