Enhanced NK-92 Cytotoxicity by CRISPR Genome Engineering Using Cas9 Ribonucleoproteins

Enhanced NK-92 Cytotoxicity by CRISPR Genome Engineering Using Cas9 Ribonucleoproteins

Natural killer (NK) cells are an attractive cell-type for adoptive immunotherapy, but challenges in preparation of therapeutic primary NK cells restrict patient accessibility to NK cell immunotherapy. NK-92 is a well-characterized human NK cell line that has demonstrated promising anti-cancer activi...

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Bibliographic Details
Main Authors: Rih-Sheng Huang, Hsin-An Shih, Min-Chi Lai, Yao-Jen Chang, Steven Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Immunology
Subjects:
CRISPR
Cas9
RNP
nucleofection
NK-92
immunotherapy
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01008/full

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