Mechanisms and Perspectives of Sodium-Glucose Co-transporter 2 Inhibitors in Heart Failure
Heart failure (HF) is a common complication or late-stage manifestation of various heart diseases. Numerous risk factors and underlying causes may contribute to the occurrence and progression of HF. The pathophysiological mechanisms of HF are very complicated. Despite accumulating advances in treatm...
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doaj-ff172dc719ef49f380237e8807f46bbc2021-02-10T04:56:58ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2021-02-01810.3389/fcvm.2021.636152636152Mechanisms and Perspectives of Sodium-Glucose Co-transporter 2 Inhibitors in Heart FailureQingchun Zeng0Qingchun Zeng1Qingchun Zeng2Qing Zhou3Qing Zhou4Weitao Liu5Yutong Wang6Xingbo Xu7Dingli Xu8Dingli Xu9Dingli Xu10State Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Shock and Microcirculation, Southern Medical University, Guangzhou, ChinaBioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, ChinaState Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Cardiology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, ChinaState Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaState Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Cardiology and Pneumology, University Medical Center of Göttingen, Georg-August-University, Göttingen, GermanyState Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Shock and Microcirculation, Southern Medical University, Guangzhou, ChinaBioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, ChinaHeart failure (HF) is a common complication or late-stage manifestation of various heart diseases. Numerous risk factors and underlying causes may contribute to the occurrence and progression of HF. The pathophysiological mechanisms of HF are very complicated. Despite accumulating advances in treatment for HF during recent decades, it remains an intractable clinical syndrome with poor outcomes, significantly reducing the quality of life and expectancy of patients, and imposing a heavy economic burden on society and families. Although initially classified as antidiabetic agents, sodium-glucose co-transporter 2 (SGLT2) inhibitors have demonstrated reduced the prevalence of hospitalization for HF, cardiovascular death, and all-cause death in several large-scale randomized controlled clinical trials. These beneficial effects of SGLT-2 inhibitors can be attributed to multiple hemodynamic, inflammatory and metabolic mechanisms, not only reducing the serum glucose level. SGLT2 inhibitors have been used increasingly in treatment for patients with HF with reduced ejection fraction due to their surprising performance in improving the prognosis. In addition, their roles and mechanisms in patients with HF with preserved ejection fraction or acute HF have also attracted attention. In this review article, we discuss the possible mechanisms and applications of SGLT2 inhibitors in HF.https://www.frontiersin.org/articles/10.3389/fcvm.2021.636152/fullsodium-glucose co-transporter 2 inhibitorsdiabetes mellitusheart failureheart failure with preserved ejection fractioninsulin resistance |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Qingchun Zeng Qingchun Zeng Qingchun Zeng Qing Zhou Qing Zhou Weitao Liu Yutong Wang Xingbo Xu Dingli Xu Dingli Xu Dingli Xu |
spellingShingle |
Qingchun Zeng Qingchun Zeng Qingchun Zeng Qing Zhou Qing Zhou Weitao Liu Yutong Wang Xingbo Xu Dingli Xu Dingli Xu Dingli Xu Mechanisms and Perspectives of Sodium-Glucose Co-transporter 2 Inhibitors in Heart Failure Frontiers in Cardiovascular Medicine sodium-glucose co-transporter 2 inhibitors diabetes mellitus heart failure heart failure with preserved ejection fraction insulin resistance |
author_facet |
Qingchun Zeng Qingchun Zeng Qingchun Zeng Qing Zhou Qing Zhou Weitao Liu Yutong Wang Xingbo Xu Dingli Xu Dingli Xu Dingli Xu |
author_sort |
Qingchun Zeng |
title |
Mechanisms and Perspectives of Sodium-Glucose Co-transporter 2 Inhibitors in Heart Failure |
title_short |
Mechanisms and Perspectives of Sodium-Glucose Co-transporter 2 Inhibitors in Heart Failure |
title_full |
Mechanisms and Perspectives of Sodium-Glucose Co-transporter 2 Inhibitors in Heart Failure |
title_fullStr |
Mechanisms and Perspectives of Sodium-Glucose Co-transporter 2 Inhibitors in Heart Failure |
title_full_unstemmed |
Mechanisms and Perspectives of Sodium-Glucose Co-transporter 2 Inhibitors in Heart Failure |
title_sort |
mechanisms and perspectives of sodium-glucose co-transporter 2 inhibitors in heart failure |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cardiovascular Medicine |
issn |
2297-055X |
publishDate |
2021-02-01 |
description |
Heart failure (HF) is a common complication or late-stage manifestation of various heart diseases. Numerous risk factors and underlying causes may contribute to the occurrence and progression of HF. The pathophysiological mechanisms of HF are very complicated. Despite accumulating advances in treatment for HF during recent decades, it remains an intractable clinical syndrome with poor outcomes, significantly reducing the quality of life and expectancy of patients, and imposing a heavy economic burden on society and families. Although initially classified as antidiabetic agents, sodium-glucose co-transporter 2 (SGLT2) inhibitors have demonstrated reduced the prevalence of hospitalization for HF, cardiovascular death, and all-cause death in several large-scale randomized controlled clinical trials. These beneficial effects of SGLT-2 inhibitors can be attributed to multiple hemodynamic, inflammatory and metabolic mechanisms, not only reducing the serum glucose level. SGLT2 inhibitors have been used increasingly in treatment for patients with HF with reduced ejection fraction due to their surprising performance in improving the prognosis. In addition, their roles and mechanisms in patients with HF with preserved ejection fraction or acute HF have also attracted attention. In this review article, we discuss the possible mechanisms and applications of SGLT2 inhibitors in HF. |
topic |
sodium-glucose co-transporter 2 inhibitors diabetes mellitus heart failure heart failure with preserved ejection fraction insulin resistance |
url |
https://www.frontiersin.org/articles/10.3389/fcvm.2021.636152/full |
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