Mechanisms and Perspectives of Sodium-Glucose Co-transporter 2 Inhibitors in Heart Failure

Heart failure (HF) is a common complication or late-stage manifestation of various heart diseases. Numerous risk factors and underlying causes may contribute to the occurrence and progression of HF. The pathophysiological mechanisms of HF are very complicated. Despite accumulating advances in treatm...

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Main Authors: Qingchun Zeng, Qing Zhou, Weitao Liu, Yutong Wang, Xingbo Xu, Dingli Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.636152/full
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spelling doaj-ff172dc719ef49f380237e8807f46bbc2021-02-10T04:56:58ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2021-02-01810.3389/fcvm.2021.636152636152Mechanisms and Perspectives of Sodium-Glucose Co-transporter 2 Inhibitors in Heart FailureQingchun Zeng0Qingchun Zeng1Qingchun Zeng2Qing Zhou3Qing Zhou4Weitao Liu5Yutong Wang6Xingbo Xu7Dingli Xu8Dingli Xu9Dingli Xu10State Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Shock and Microcirculation, Southern Medical University, Guangzhou, ChinaBioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, ChinaState Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Cardiology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, ChinaState Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaState Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Cardiology and Pneumology, University Medical Center of Göttingen, Georg-August-University, Göttingen, GermanyState Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Shock and Microcirculation, Southern Medical University, Guangzhou, ChinaBioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, ChinaHeart failure (HF) is a common complication or late-stage manifestation of various heart diseases. Numerous risk factors and underlying causes may contribute to the occurrence and progression of HF. The pathophysiological mechanisms of HF are very complicated. Despite accumulating advances in treatment for HF during recent decades, it remains an intractable clinical syndrome with poor outcomes, significantly reducing the quality of life and expectancy of patients, and imposing a heavy economic burden on society and families. Although initially classified as antidiabetic agents, sodium-glucose co-transporter 2 (SGLT2) inhibitors have demonstrated reduced the prevalence of hospitalization for HF, cardiovascular death, and all-cause death in several large-scale randomized controlled clinical trials. These beneficial effects of SGLT-2 inhibitors can be attributed to multiple hemodynamic, inflammatory and metabolic mechanisms, not only reducing the serum glucose level. SGLT2 inhibitors have been used increasingly in treatment for patients with HF with reduced ejection fraction due to their surprising performance in improving the prognosis. In addition, their roles and mechanisms in patients with HF with preserved ejection fraction or acute HF have also attracted attention. In this review article, we discuss the possible mechanisms and applications of SGLT2 inhibitors in HF.https://www.frontiersin.org/articles/10.3389/fcvm.2021.636152/fullsodium-glucose co-transporter 2 inhibitorsdiabetes mellitusheart failureheart failure with preserved ejection fractioninsulin resistance
collection DOAJ
language English
format Article
sources DOAJ
author Qingchun Zeng
Qingchun Zeng
Qingchun Zeng
Qing Zhou
Qing Zhou
Weitao Liu
Yutong Wang
Xingbo Xu
Dingli Xu
Dingli Xu
Dingli Xu
spellingShingle Qingchun Zeng
Qingchun Zeng
Qingchun Zeng
Qing Zhou
Qing Zhou
Weitao Liu
Yutong Wang
Xingbo Xu
Dingli Xu
Dingli Xu
Dingli Xu
Mechanisms and Perspectives of Sodium-Glucose Co-transporter 2 Inhibitors in Heart Failure
Frontiers in Cardiovascular Medicine
sodium-glucose co-transporter 2 inhibitors
diabetes mellitus
heart failure
heart failure with preserved ejection fraction
insulin resistance
author_facet Qingchun Zeng
Qingchun Zeng
Qingchun Zeng
Qing Zhou
Qing Zhou
Weitao Liu
Yutong Wang
Xingbo Xu
Dingli Xu
Dingli Xu
Dingli Xu
author_sort Qingchun Zeng
title Mechanisms and Perspectives of Sodium-Glucose Co-transporter 2 Inhibitors in Heart Failure
title_short Mechanisms and Perspectives of Sodium-Glucose Co-transporter 2 Inhibitors in Heart Failure
title_full Mechanisms and Perspectives of Sodium-Glucose Co-transporter 2 Inhibitors in Heart Failure
title_fullStr Mechanisms and Perspectives of Sodium-Glucose Co-transporter 2 Inhibitors in Heart Failure
title_full_unstemmed Mechanisms and Perspectives of Sodium-Glucose Co-transporter 2 Inhibitors in Heart Failure
title_sort mechanisms and perspectives of sodium-glucose co-transporter 2 inhibitors in heart failure
publisher Frontiers Media S.A.
series Frontiers in Cardiovascular Medicine
issn 2297-055X
publishDate 2021-02-01
description Heart failure (HF) is a common complication or late-stage manifestation of various heart diseases. Numerous risk factors and underlying causes may contribute to the occurrence and progression of HF. The pathophysiological mechanisms of HF are very complicated. Despite accumulating advances in treatment for HF during recent decades, it remains an intractable clinical syndrome with poor outcomes, significantly reducing the quality of life and expectancy of patients, and imposing a heavy economic burden on society and families. Although initially classified as antidiabetic agents, sodium-glucose co-transporter 2 (SGLT2) inhibitors have demonstrated reduced the prevalence of hospitalization for HF, cardiovascular death, and all-cause death in several large-scale randomized controlled clinical trials. These beneficial effects of SGLT-2 inhibitors can be attributed to multiple hemodynamic, inflammatory and metabolic mechanisms, not only reducing the serum glucose level. SGLT2 inhibitors have been used increasingly in treatment for patients with HF with reduced ejection fraction due to their surprising performance in improving the prognosis. In addition, their roles and mechanisms in patients with HF with preserved ejection fraction or acute HF have also attracted attention. In this review article, we discuss the possible mechanisms and applications of SGLT2 inhibitors in HF.
topic sodium-glucose co-transporter 2 inhibitors
diabetes mellitus
heart failure
heart failure with preserved ejection fraction
insulin resistance
url https://www.frontiersin.org/articles/10.3389/fcvm.2021.636152/full
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