Synthesis of Fluorine Heterocyclic Nitrogen Systems Derived From Sulfa Drugs as PhotochemicalProbe Agents for Inhibition of Vitiligo Disease-Part II

Synthesis of Fluorine Heterocyclic Nitrogen Systems Derived From Sulfa Drugs as PhotochemicalProbe Agents for Inhibition of Vitiligo Disease-Part II

Some more new bioactive fluorine heterocyclic systems containing sulfur and nitrogen as six-membered rings such as; N,Nʼ-disubstituted-thiobarbituric acid, 3-thioxo-1,2,4-triazino[5,6-b]indole, 3-sulfanilamido-1,2,4-triazino[5,6-b]indole and 2-trifluoromethyl-4-imino-6-(sulfamido)1,3,5-triazino [3,2...

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Main Authors: Reda M. Abdel-Rahman, Mohammad Saleh I. T. Makki, Wafa A. Baker Bawazir
Format: Article
Language:English
Published: Hindawi Limited 2010-01-01
Series:E-Journal of Chemistry
Online Access:http://dx.doi.org/10.1155/2010/467564
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spelling doaj-ff1693c0c07f46a4a3a53fb43fa22c022020-11-24T21:32:26ZengHindawi LimitedE-Journal of Chemistry0973-49452090-98102010-01-017S1S93S10210.1155/2010/467564Synthesis of Fluorine Heterocyclic Nitrogen Systems Derived From Sulfa Drugs as PhotochemicalProbe Agents for Inhibition of Vitiligo Disease-Part IIReda M. Abdel-Rahman0Mohammad Saleh I. T. Makki1Wafa A. Baker Bawazir2Department of Chemistry, Faculty of Science, King Abdul-Aziz University, P.O.Box 80203, Jeddah 21315, Saudi ArabiaDepartment of Chemistry, Faculty of Science, King Abdul-Aziz University, P.O.Box 80203, Jeddah 21315, Saudi ArabiaDepartment of Chemistry, Faculty of Science, King Abdul-Aziz University, P.O.Box 80203, Jeddah 21315, Saudi ArabiaSome more new bioactive fluorine heterocyclic systems containing sulfur and nitrogen as six-membered rings such as; N,Nʼ-disubstituted-thiobarbituric acid, 3-thioxo-1,2,4-triazino[5,6-b]indole, 3-sulfanilamido-1,2,4-triazino[5,6-b]indole and 2-trifluoromethyl-4-imino-6-(sulfamido)1,3,5-triazino [3,2-a]indole derivatives (2-13) have been synthetically derived from the interaction of sulfa drugs with fluorine organic compounds (aldehydes, ketones, anhydride) followed by ring closure reactions. Structures of the targets have been established from their elemental and spectral data. Compounds 3, 6, 10 and 13 could be used as photochemical probe agents in compared with nystatin and nalidixic acid for inhibition of vitiligo diseases.http://dx.doi.org/10.1155/2010/467564
collection DOAJ
language English
format Article
sources DOAJ
author Reda M. Abdel-Rahman
Mohammad Saleh I. T. Makki
Wafa A. Baker Bawazir
spellingShingle Reda M. Abdel-Rahman
Mohammad Saleh I. T. Makki
Wafa A. Baker Bawazir
Synthesis of Fluorine Heterocyclic Nitrogen Systems Derived From Sulfa Drugs as PhotochemicalProbe Agents for Inhibition of Vitiligo Disease-Part II
E-Journal of Chemistry
author_facet Reda M. Abdel-Rahman
Mohammad Saleh I. T. Makki
Wafa A. Baker Bawazir
author_sort Reda M. Abdel-Rahman
title Synthesis of Fluorine Heterocyclic Nitrogen Systems Derived From Sulfa Drugs as PhotochemicalProbe Agents for Inhibition of Vitiligo Disease-Part II
title_short Synthesis of Fluorine Heterocyclic Nitrogen Systems Derived From Sulfa Drugs as PhotochemicalProbe Agents for Inhibition of Vitiligo Disease-Part II
title_full Synthesis of Fluorine Heterocyclic Nitrogen Systems Derived From Sulfa Drugs as PhotochemicalProbe Agents for Inhibition of Vitiligo Disease-Part II
title_fullStr Synthesis of Fluorine Heterocyclic Nitrogen Systems Derived From Sulfa Drugs as PhotochemicalProbe Agents for Inhibition of Vitiligo Disease-Part II
title_full_unstemmed Synthesis of Fluorine Heterocyclic Nitrogen Systems Derived From Sulfa Drugs as PhotochemicalProbe Agents for Inhibition of Vitiligo Disease-Part II
title_sort synthesis of fluorine heterocyclic nitrogen systems derived from sulfa drugs as photochemicalprobe agents for inhibition of vitiligo disease-part ii
publisher Hindawi Limited
series E-Journal of Chemistry
issn 0973-4945
2090-9810
publishDate 2010-01-01
description Some more new bioactive fluorine heterocyclic systems containing sulfur and nitrogen as six-membered rings such as; N,Nʼ-disubstituted-thiobarbituric acid, 3-thioxo-1,2,4-triazino[5,6-b]indole, 3-sulfanilamido-1,2,4-triazino[5,6-b]indole and 2-trifluoromethyl-4-imino-6-(sulfamido)1,3,5-triazino [3,2-a]indole derivatives (2-13) have been synthetically derived from the interaction of sulfa drugs with fluorine organic compounds (aldehydes, ketones, anhydride) followed by ring closure reactions. Structures of the targets have been established from their elemental and spectral data. Compounds 3, 6, 10 and 13 could be used as photochemical probe agents in compared with nystatin and nalidixic acid for inhibition of vitiligo diseases.
url http://dx.doi.org/10.1155/2010/467564
work_keys_str_mv AT redamabdelrahman synthesisoffluorineheterocyclicnitrogensystemsderivedfromsulfadrugsasphotochemicalprobeagentsforinhibitionofvitiligodiseasepartii
AT mohammadsalehitmakki synthesisoffluorineheterocyclicnitrogensystemsderivedfromsulfadrugsasphotochemicalprobeagentsforinhibitionofvitiligodiseasepartii
AT wafaabakerbawazir synthesisoffluorineheterocyclicnitrogensystemsderivedfromsulfadrugsasphotochemicalprobeagentsforinhibitionofvitiligodiseasepartii
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