Anti-vascular Endothelial Growth Factor Outpatient Treatment Patterns in Patients with Exudative Age-related Macular Degeneration from a Japanese Hospital Claims Database

**Purpose:** To identify outpatient treatment patterns of patients with exudative age-related macular degeneration (AMD) who received approved anti–vascular endothelial growth factor (VEGF) therapy, using real-world data from hospitals in Japan. **Methods:** A hospital claims database was retrospec...

Full description

Bibliographic Details
Main Authors: Tomohiro Iida, Aya Narimatsu, Kenji Adachi, Edward CY Wang
Format: Article
Language:English
Published: Columbia Data Analytics, LLC
Series:Journal of Health Economics and Outcomes Research
Online Access:http://jheor.scholasticahq.com/article/9887-anti-vascular-endothelial-growth-factor-outpatient-treatment-patterns-in-patients-with-exudative-age-related-macular-degeneration-from-a-japanese-hospital-claims-database.pdf
id doaj-ff099f435ee940afb9a7df57d8ab4be7
record_format Article
spelling doaj-ff099f435ee940afb9a7df57d8ab4be72020-11-25T01:56:16ZengColumbia Data Analytics, LLCJournal of Health Economics and Outcomes Research2327-2236Anti-vascular Endothelial Growth Factor Outpatient Treatment Patterns in Patients with Exudative Age-related Macular Degeneration from a Japanese Hospital Claims DatabaseTomohiro IidaAya NarimatsuKenji AdachiEdward CY Wang**Purpose:** To identify outpatient treatment patterns of patients with exudative age-related macular degeneration (AMD) who received approved anti–vascular endothelial growth factor (VEGF) therapy, using real-world data from hospitals in Japan. **Methods:** A hospital claims database was retrospectively reviewed for patients diagnosed with exudative AMD who were treated with anti-VEGF therapy in the outpatient setting between January 2010 and December 2012. Within a treatment period of at least 12 months, the frequency of anti-VEGF injections and AMD-related visits, and time intervals between AMD-related visits and anti-VEGF injections were captured for patients who had neither cataracts nor glaucoma. “Loading dose regimen” was defined as the first 2 or 3 monthly doses and “PRN maintenance regimen” (where PRN=pro re nata) was defined as the entire period of time after the loading doses had been administered. **Results:** Claims data were collected from a total of 219 patients from 13 of 126 hospitals: 217 treated with ranibizumab (8 received pegaptanib as well), 2 with aflibercept. Of these, 68 patients were treated for at least 12 months (all with ranibizumab PRN), and 29 had neither cataracts nor glaucoma and were included in the treatment pattern analysis. These 29 patients received a mean of 3.8 injections in the first 12 months and another 2.5 injections in the second 12 months of treatment. The average number of all outpatient visits was 16.1 in the first 12 months and 13.7 in the second 12 months, and an average of 11.6 days elapsed between injections and the previous outpatient monitoring visits using a PRN schedule. **Conclusion:** In a real-world setting in Japan, anti-VEGF PRN injections are administered less frequently than in clinical trials, and with time between monitoring and re-injection visits. Nonetheless, patients still visit the hospital frequently, which can significantly burden patients, caregivers, and healthcare providers.http://jheor.scholasticahq.com/article/9887-anti-vascular-endothelial-growth-factor-outpatient-treatment-patterns-in-patients-with-exudative-age-related-macular-degeneration-from-a-japanese-hospital-claims-database.pdf
collection DOAJ
language English
format Article
sources DOAJ
author Tomohiro Iida
Aya Narimatsu
Kenji Adachi
Edward CY Wang
spellingShingle Tomohiro Iida
Aya Narimatsu
Kenji Adachi
Edward CY Wang
Anti-vascular Endothelial Growth Factor Outpatient Treatment Patterns in Patients with Exudative Age-related Macular Degeneration from a Japanese Hospital Claims Database
Journal of Health Economics and Outcomes Research
author_facet Tomohiro Iida
Aya Narimatsu
Kenji Adachi
Edward CY Wang
author_sort Tomohiro Iida
title Anti-vascular Endothelial Growth Factor Outpatient Treatment Patterns in Patients with Exudative Age-related Macular Degeneration from a Japanese Hospital Claims Database
title_short Anti-vascular Endothelial Growth Factor Outpatient Treatment Patterns in Patients with Exudative Age-related Macular Degeneration from a Japanese Hospital Claims Database
title_full Anti-vascular Endothelial Growth Factor Outpatient Treatment Patterns in Patients with Exudative Age-related Macular Degeneration from a Japanese Hospital Claims Database
title_fullStr Anti-vascular Endothelial Growth Factor Outpatient Treatment Patterns in Patients with Exudative Age-related Macular Degeneration from a Japanese Hospital Claims Database
title_full_unstemmed Anti-vascular Endothelial Growth Factor Outpatient Treatment Patterns in Patients with Exudative Age-related Macular Degeneration from a Japanese Hospital Claims Database
title_sort anti-vascular endothelial growth factor outpatient treatment patterns in patients with exudative age-related macular degeneration from a japanese hospital claims database
publisher Columbia Data Analytics, LLC
series Journal of Health Economics and Outcomes Research
issn 2327-2236
description **Purpose:** To identify outpatient treatment patterns of patients with exudative age-related macular degeneration (AMD) who received approved anti–vascular endothelial growth factor (VEGF) therapy, using real-world data from hospitals in Japan. **Methods:** A hospital claims database was retrospectively reviewed for patients diagnosed with exudative AMD who were treated with anti-VEGF therapy in the outpatient setting between January 2010 and December 2012. Within a treatment period of at least 12 months, the frequency of anti-VEGF injections and AMD-related visits, and time intervals between AMD-related visits and anti-VEGF injections were captured for patients who had neither cataracts nor glaucoma. “Loading dose regimen” was defined as the first 2 or 3 monthly doses and “PRN maintenance regimen” (where PRN=pro re nata) was defined as the entire period of time after the loading doses had been administered. **Results:** Claims data were collected from a total of 219 patients from 13 of 126 hospitals: 217 treated with ranibizumab (8 received pegaptanib as well), 2 with aflibercept. Of these, 68 patients were treated for at least 12 months (all with ranibizumab PRN), and 29 had neither cataracts nor glaucoma and were included in the treatment pattern analysis. These 29 patients received a mean of 3.8 injections in the first 12 months and another 2.5 injections in the second 12 months of treatment. The average number of all outpatient visits was 16.1 in the first 12 months and 13.7 in the second 12 months, and an average of 11.6 days elapsed between injections and the previous outpatient monitoring visits using a PRN schedule. **Conclusion:** In a real-world setting in Japan, anti-VEGF PRN injections are administered less frequently than in clinical trials, and with time between monitoring and re-injection visits. Nonetheless, patients still visit the hospital frequently, which can significantly burden patients, caregivers, and healthcare providers.
url http://jheor.scholasticahq.com/article/9887-anti-vascular-endothelial-growth-factor-outpatient-treatment-patterns-in-patients-with-exudative-age-related-macular-degeneration-from-a-japanese-hospital-claims-database.pdf
work_keys_str_mv AT tomohiroiida antivascularendothelialgrowthfactoroutpatienttreatmentpatternsinpatientswithexudativeagerelatedmaculardegenerationfromajapanesehospitalclaimsdatabase
AT ayanarimatsu antivascularendothelialgrowthfactoroutpatienttreatmentpatternsinpatientswithexudativeagerelatedmaculardegenerationfromajapanesehospitalclaimsdatabase
AT kenjiadachi antivascularendothelialgrowthfactoroutpatienttreatmentpatternsinpatientswithexudativeagerelatedmaculardegenerationfromajapanesehospitalclaimsdatabase
AT edwardcywang antivascularendothelialgrowthfactoroutpatienttreatmentpatternsinpatientswithexudativeagerelatedmaculardegenerationfromajapanesehospitalclaimsdatabase
_version_ 1724980523897454592